Molecular aspects of cardiovascular & brain-related disorders Flashcards
what is the cardiovascular system responsible for?
transport of oxygen, nutrients,, hormones, waste
pulmonary circulation
deoxygenated blood to the lungs
systemic circulation
highly oxygenated blood to the tissue
arteries
high pressure, away from the heart
veins
low pressure, to the heart
capillaries
exchange of O2, nutrients to the tissue
cardiovascular disease (CD)
any disease that affects the cardiovascular system
cerebrovascular disease
disruption of blood supply to the brain
aortic aneurism & dissection
dilatation/rupture of the aorta
peripheral arterial disease
of arteries supplying arms/legs
deep venous thrombosis & pulmonary embolism
blood clots in the leg veins which can dislodge and move to heart/lungs
coronary heart disease
of blood vessel supplying the heart muscles
rheumatic heart disease
damage to heart muscle and valves from rheumatic fever (caused by streptococcal infection)
congenital heart disease
malformations of heart structures existing at birth
non-modifiable risk factors for developing CVDs
- advancing age
- genetic predisposition
- gender
modifiable risk factors for developing CVDs
- tobacco smoking, physical inactivity, poor diet, excessive alcohol
- high blood pressure/blood lipids (cholesterol), obesity
- diabetes
describe the stages of atherosclerosis
- fatty streak formation
- plaque progression (adaption)
- plaque disruption (clinical manifestation)
stage 1 of atherosclerosis (fatty streak formation)
- endothelial cell dysfunction
- lipoprotein entry & modification
- leukocyte recruitment & foam cell formation
- > impaired trafficking, local accumulation of macrophages, failure to resolve inflammation
endothelial cell dysfunction
vasoconstriction, lipoprotein oxidation, pro-inflammatory genes, NO-catabolism
lipoprotein entry
LDL binds to proteoglycans and accumulates (adds cholesterol)
how can HDL protect against atherosclerosis?
removes excess cholesterol
LDL / HDL
low/high density lipoprotein