MODY

Question 1

What does MODY stand for?

Answer 1

Mature onset diabetes of the young

Question 2

What inheritance pattern does MODY usually follow?

Answer 2

Autosomal dominant

Question 3

Is MODY insulin-dependent?

Answer 3

No

Question 4

What is the age of onset of MODY?

Answer 4

Before age of 25

Question 5

What are the 2 main distinct types of MODY?

Answer 5

Transcription factor mutations (HNF-1alpha)

Glucokinase mutation

Question 6

At what age does glucokinase mutation related MODY onset?

Answer 6

Birth

Question 7

At what age does transcription factor mutation related MODY onset?

Answer 7

Adolescence/young adulthood

Question 8

Glucokinase mutation related MODY involves unstable hyperglycaemia. True/False?

Answer 8

False

Stable hyperglycaemia

Question 9

Glucokinase mutation related MODY has better prognosis than transcription factor mutation related MODY. True/False?

Answer 9

True

Question 10

Neonatal diabetes requires insulin treatment within the first 3 months of life. True/False?

Answer 10

True

Question 11

Which drug class is good for transcription factor mutation related MODY?

Answer 11

Sulphonylureas