Module3: Drug metabolism and Transport

Question 1

what is the primary role of metabolism?

Answer 1

To make drugs more water soluble

Question 2

where does most metabolism occur?

Answer 2

The liver

Question 3

what does low metabolism lead to

Answer 3

Delayed elimination

Question 4

saturable metabolism

Question 5

Prodrug

Question 6

what is drug metabolism dependent on?

Answer 6

Protein activity

Question 7

CYP2D6

Question 8

CYP2C19

Question 9

TPMT

Question 10

polymorphism

Question 11

phase 1 reactions

Question 12

phase 2 reactions

Question 13

solute carriers

Question 14

which transporters are solute carriers?

Answer 14

OATP, OAT, OCT, PEPT, MCT

Question 15

which transporters are on the apical side?

Question 16

OCT2 deficiency is protective (T/F)

Answer 16

True

Question 17

basolateral

Question 18

which transporters mediate uptake into enterocytes?

Answer 18

OATP1A2 and OATP2B1

Question 19

apical

Question 20

canicular

Question 21

Most important CYP enzyme present in the liver and responsible for 40-50% of metabolism

Question 22

Transport proteins that are present on the hepatocyte canicular membrane and are important for biliary elimination

Question 23

major elimination pathway thats dependent on UGT

Answer 23

Glucoronidation

Question 24

phase 2 reaction thats carried out by sulfotransferases

Answer 24

Sulfation