Module Drug List Summarised Flashcards
What is the pharmacological action of Ketamine?
NMDA glutamate receptor channel blocker
For which condition is Lamotrigine commonly used?
Epilepsy
What is the pharmacological action of Maprotiline?
NA reuptake transporter blocker (antidepressant)
MDMA primarily blocks the reuptake of which neurotransmitter and promotes its reverse transport?
5HT (Serotonin)
Midazolam belongs to which class of drugs and what is its pharmacological effect?
- It is a benzodiazepine agonist
- acts as a sedative and anticonvulsant
Minoxidil is known to open which type of potassium channels?
ATP-dependent K+ channels
Nicotine stimulates which type of postsynaptic receptors?
- Muscarinic acetylcholine receptors (mACh receptors)
Olanzapine primarily acts as an antagonist for which receptors?
5HT2 (Serotonin) and D4 (Dopamine) receptors
What is the mechanism of action of PCPA (para-Chlorophenylalanine)?
- inactivates the synthetic enzyme and inhibits the synthesis of serotonin in the presynaptic terminal.
How does Phenobarbital exert its effect?
- opens GABA receptors (a barbiturate)
Phenytoin blocks which types of channels to decrease neuronal excitation?
- Voltage-gated sodium channels (VGCCs)
- voltage-gated N-type calcium channels (VGNCs)
What is the pharmacological action of Physostigmine?
It inactivates acetylcholinesterases on the postsynaptic membrane
Picrotoxin promotes seizures by blocking which type of conductance?
Chloride ion (Cl-) conductance
Pregabalin is used as an anticonvulsant and for neuropathic pain. How does it exert its effect?
It acts like GABA, binds to VGCCs, and inhibits the release of neurotransmitters.
Rasagiline is used in the treatment of Parkinson’s disease. What is its mechanism of action?
It is a MAO-B inhibitor
Reboxetine is an antidepressant that blocks which transporter?
Norepinephrine (NA) reuptake transporter
Reserpine prevents the storage of neurotransmitters in vesicles. True or False?
True
Selegiline is used in the treatment of Parkinson’s disease. What is its mechanism of action?
- It is a MAO-B inhibitor
Sibutramine, which is no longer used, acted as an anti-obesity agent by blocking the reuptake of which neurotransmitters?
- Norepinephrine (NA) and Serotonin (5HT)
What is the pharmacological action of Sodium Valproate?
It blocks voltage-gated calcium channels (VGCs) and inhibits GABA transaminase
Tetrabenazine is used in the treatment of which condition?
Huntington’s disease
What is the mechanism of action of Tetrodotoxin?
blocks voltage-gated sodium channels (VGSCs)
Tiagabine is an antiepileptic drug. What is its pharmacological action?
- a GABA transporter blocker, which increases inhibition and blocks seizures
For which condition is Tolcapone used in the treatment?
Parkinson’s disease (rarely used)
Triptans are used for the treatment of migraines and headaches. What is their pharmacological action?
- They are 5HT agonists and inhibit the release of calcitonin gene-related peptide
What is the mechanism of action of NSAIDs?
- They block COX enzymes that produce pain chemicals
What is the full form of SSRI, and what is its mode of action?
- SSRI stands for Selective Serotonin Reuptake Inhibitor
- It blocks the reuptake of serotonin
SSRI stands for Selective Serotonin Reuptake Inhibitor. It blocks the reuptake of serotonin
- SNRI stands for Serotonin and Norepinephrine Reuptake Inhibitor
- It blocks the reuptake of serotonin and norepinephrine
