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5BBM0218 Physiology and Pharmacology of CNS > Module Drug List Summarised > Flashcards

Module Drug List Summarised Flashcards

1
Q

What is the pharmacological action of Ketamine?

A

NMDA glutamate receptor channel blocker

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2
Q

For which condition is Lamotrigine commonly used?

A

Epilepsy

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3
Q

What is the pharmacological action of Maprotiline?

A

NA reuptake transporter blocker (antidepressant)

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4
Q

MDMA primarily blocks the reuptake of which neurotransmitter and promotes its reverse transport?

A

5HT (Serotonin)

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5
Q

Midazolam belongs to which class of drugs and what is its pharmacological effect?

A
  • It is a benzodiazepine agonist
  • acts as a sedative and anticonvulsant
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6
Q

Minoxidil is known to open which type of potassium channels?

A

ATP-dependent K+ channels

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7
Q

Nicotine stimulates which type of postsynaptic receptors?

A
  • Muscarinic acetylcholine receptors (mACh receptors)
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8
Q

Olanzapine primarily acts as an antagonist for which receptors?

A

5HT2 (Serotonin) and D4 (Dopamine) receptors

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9
Q

What is the mechanism of action of PCPA (para-Chlorophenylalanine)?

A
  • inactivates the synthetic enzyme and inhibits the synthesis of serotonin in the presynaptic terminal.
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10
Q

How does Phenobarbital exert its effect?

A
  • opens GABA receptors (a barbiturate)
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11
Q

Phenytoin blocks which types of channels to decrease neuronal excitation?

A
  • Voltage-gated sodium channels (VGCCs)
  • voltage-gated N-type calcium channels (VGNCs)
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12
Q

What is the pharmacological action of Physostigmine?

A

It inactivates acetylcholinesterases on the postsynaptic membrane

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13
Q

Picrotoxin promotes seizures by blocking which type of conductance?

A

Chloride ion (Cl-) conductance

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14
Q

Pregabalin is used as an anticonvulsant and for neuropathic pain. How does it exert its effect?

A

It acts like GABA, binds to VGCCs, and inhibits the release of neurotransmitters.

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15
Q

Rasagiline is used in the treatment of Parkinson’s disease. What is its mechanism of action?

A

It is a MAO-B inhibitor

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16
Q

Reboxetine is an antidepressant that blocks which transporter?

A

Norepinephrine (NA) reuptake transporter

17
Q

Reserpine prevents the storage of neurotransmitters in vesicles. True or False?

A

True

18
Q

Selegiline is used in the treatment of Parkinson’s disease. What is its mechanism of action?

A
  • It is a MAO-B inhibitor
19
Q

Sibutramine, which is no longer used, acted as an anti-obesity agent by blocking the reuptake of which neurotransmitters?

A
  • Norepinephrine (NA) and Serotonin (5HT)
20
Q

What is the pharmacological action of Sodium Valproate?

A

It blocks voltage-gated calcium channels (VGCs) and inhibits GABA transaminase

21
Q

Tetrabenazine is used in the treatment of which condition?

A

Huntington’s disease

22
Q

What is the mechanism of action of Tetrodotoxin?

A

blocks voltage-gated sodium channels (VGSCs)

23
Q

Tiagabine is an antiepileptic drug. What is its pharmacological action?

A
  • a GABA transporter blocker, which increases inhibition and blocks seizures
24
Q

For which condition is Tolcapone used in the treatment?

A

Parkinson’s disease (rarely used)

25
Q

Triptans are used for the treatment of migraines and headaches. What is their pharmacological action?

A
  • They are 5HT agonists and inhibit the release of calcitonin gene-related peptide
26
Q

What is the mechanism of action of NSAIDs?

A
  • They block COX enzymes that produce pain chemicals
27
Q

What is the full form of SSRI, and what is its mode of action?

A
  • SSRI stands for Selective Serotonin Reuptake Inhibitor
  • It blocks the reuptake of serotonin
28
Q

SSRI stands for Selective Serotonin Reuptake Inhibitor. It blocks the reuptake of serotonin

A
  • SNRI stands for Serotonin and Norepinephrine Reuptake Inhibitor
  • It blocks the reuptake of serotonin and norepinephrine

5BBM0218 Physiology and Pharmacology of CNS (17 decks)

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