Module 9 Flashcards
What one letter always comes before the suffix in Amide LA generic names?
i
All Amides end in what suffix?
Caine
What was the very first LA in dentistry?
Novacaine
What are two other names for Novacaine?
Procaine
Propoxycaine
What year did Amides take over?
1940
Generic Name: Articaine
What are the trade names it’s also known by?
SOAZ
Septocaine
Orabloc
Articadent
Zorcaine
Generic Name: Prilocaine
What are the trade names it’s also known by
Citanest
Generic Name: Lidocaine
What are the trade names it’s also known by
LOX
Lignospan
Octocaine
Xylocaine
Generic Name: Bupivicaine
What are the trade names it’s also known by
MV
Marcaine
Vivicaine
Generic Name: Mepivicaine
What are the trade names it’s also known by
PICS
Polocaine
Isocaine
Carbocaine
Scandanest
What problem does someone have who is allergic to Esters?
Atypical Plasma Cholinesterase
If someone has ever been diagnosed with Methhemoglobinemia what LA can we NOT use?
Prilocaine (Citanest)
If someone has significant cardiac problems what do we have to limit our use of?
Epinephrine
What two LA’s can we use without worry on someone with significant cardiac issues?
Mepivicaine 3% (plain)
Prilocaine 4%
If someone has clinical hyperthyroidism we have to stay away from what?
Racemic epinephrine gingival retraction cord
What are two types of LA someone can have an actual allergy to?
Esters
Bisulfites
If someone is allergic to Bisulfites what can we NOT give them?
LA with vasoconstrictors
Because it has to be mixed with Bisulfites to preserve it from expiring fast
What are 5 things that influence the duration if LA?
Type of injection Accuracy of injection technique Status of oral tissue (infections) Anatomical variations Personal response (hypo/hyper)
What type of LA responder stays numb longer?
Hyper
Hypo responders do what?
Get un-numb fast
An infiltration injection is more commonly known as a?
Supraperiosteal
If you give someone LESS than the recommended dose of LA you will have a ——– duration?
What if you gave them MORE than the recommended dose?
Shorter
No change in duration but a higher chance of toxicity
What is the #1 reason for a FAILED attempt to get someone numb?
Bad Deposition Location
If someone presents with an infection, inflamed tissues, or pain before they get an injection what two aspects of the LA will be decreased? Why?
Depth (how far into the nerve it penetrates)
Duration (time length it lasts)
Because there is an increase in vascularity so anesthetic is removed from the site of deposition faster
What is the second most common reason for a failure to anesthetize a patient?
Pt anatomy
The % listed on a carpule
(Ie: 2% Lidocaine) tells you the
——– of LA in that carpule?
Concentration in mg/ml of solution
To figure out how much DRUG is in 1 full carpule of anesthetic you take the ——— X ———-?
Concentration X 1.8ml/carpule
How much DRUG is in 1 carpule of 2% Lidocaine?
20mg/ml X 1.8ml/carpule
36mg(drug)/carpule
What is the concentration (mg/ml) for Prilocaine?
40mg/ml
What is the concentration (mg/ml) for Lidocaine?
20mg/ml
What is the concentration (mg/ml) for Mepivicaine
30mg/ml
What is the concentration (mg/ml) for Articaine
40mg/ml
What is the concentration (mg/ml) for Bupivicaine
5mg/ml
Mepivicaine is most commonly sold at a —–% or known as plain! What other concentration is it sold in?
3%
2% with vasoconstrictor
Mepivicaine 2% has ———- as it’s vasoconstrictor?
Levonordefrin
What is the ration of Levonordefrin in a carpule of Mepivicaine 2%
Why?
1:200,000
Very weak vasoconstrictor so you have to have a lot in it!!!
How many mg/ CARPULE?
Orabloc
72mg/carpule
How many mg/ CARPULE?
Isocaine
54mg/ml
How many mg/ CARPULE?
Vivicaine
9mg/carpule
How many mg/ CARPULE?
Octocaine
36mg/carpule
How many mg/ CARPULE?
Citanest
72mg/carpule
What dose MRD stand for?
Max Recommended Dose
What does ASA stand for?
American Society of Anesthesiologists
What are 3 categories of patients who we should decrease the MRD for?
Debilitated
Elderly
Medically compromised
(ASA 3/4)
Why would you use Lidocaine 2% with 1:50,000 Epi?
For hemostasis
What are two groups of Epi “sensitive” patients?
Cardiovascular patients
Clinical Hyperthyroid patients
How much epinephrine can a Epi “sensitive” patient receive?
What is the Epi MRD
0.04mg
How much epinephrine is in a cartridge with 1:100,00 Epi?
0.018mg
What is the allowable mg/lb
(of body weight) for Prilocaine
3.6mg/lb
What is the allowable mg/lb
(of body weight) for Scandanest
3.0mg/lb
What is the allowable mg/lb
(of body weight) for Zorcaine
3.2mg/ml
What is the allowable mg/lb
(of body weight) for Marcaine
0.9mg/lb
What is the allowable mg/lb
(of body weight) for Lignospan
3.2mg/lb
What LA’s have a 3.2mg/lb allowance?
Articaine
Lidocaine
Lost the LA generic names from highest to lowest allowable mg/lb ratio?
Prilocaine. 3.6
Articaine and Lidocaine. 3.2
Mepivicaine. 3.0
Bupivicaine 0.9
List the LA’s from lowest to highest MRD?
Bupivicaine. 90 Mepivicaine. 400 Lidocaine. 500 Prilocaine 600 Articaine. NA
What is the MRD for Articadent
NA
What is the MRD for Prilocaine
600
What is the MRD for Polocaine
400
What is the MRD for Bupivicaine
90
What is the MRD for Xylocaine
500
If you start with Lidocaine and switch to Mepivicaine which MRD would you stop at? Why?
Mepivicaine
Always go with the smaller MRD of the two!!!
Prilocaine can be used on —– sensitive patients?
Epi
One of the disadvantages of Prilocaine is?
Reduces O2 carrying ability due to carbon dioxide end product
Prilocaine is hydrolyzed by?
Hepatic amidases
What LA should we NEVER use for nerve blocks?
Articaine
What makes Articaine so different from other Amides?
It is a hybrid between an Ester and an Amide
Which LA is 4 times as potent as Lidocaine?
Bupivicaine
What procedures do dentists opt to use Bupivicaine? Why?
Oral surgery
Lessen the need for opioid pain killers after surgery because they stay numb for so long!!
Topical anesthetic are of what class?
Esters
What is the name of the most popular topical anesthetic?
Benzocaine
Topical anesthetics have a ——- concentration than injectables?
Higher
Topical anesthetics diffuse through ——– membranes how far?
Mucous
2-3mm
What is a side effect of topical anesthetics being so highly concentrated?
Higher chance of toxicity
Topical anesthetics are ——- in water and are absorbed ——?
Insoluble
Slowly
What does EMLA stand for?
Eutetic Mixture of Local Anesthetics
What is an EMLA made up of?
Lidocaine and Prilocaine
What is one BIG advantage of EMLA’s
Can soak through intact skin giving pupal anesthesia for a short time frame