module 7- part 1 Flashcards
Adipose tissue is ____ (very, minimally) sensitive to a persons insulin sensitivity
very
does insulin resistance occur before or after obesity/hyperglycemia
- before
insulin resistant adipose tissue associated with:
a) high blood FFA, high adiponectin,
b) dec expression of key adipogenic transcription factors, high adiponectin
c) high blood FFA, low adiponectin
d) inc expression of adipogenic transcription factors, low adiponectin
c) high bl FFA, low adiponectin
t/f insulin resistant adipose tissue is associated with dec expression of key adipogenic transcription factors
true
What did a study on blood markers in T2D show?
a) t2d higher blood insulin and glucose levels
b) higher blood NEFA and TGs
c) lower blood insulin levels
d) lower NEFA and TGs
e) a &c
f) a& d
g) a&b
h) b&c
g) a&b
Where is NEFA released from? What are they bound to?
adipose tissue depots
albumin
Which of the following is NOT a possible fate of non-esterified fatty acids (NEFA) in the liver?
A) Conversion into TAG and storage in lipid droplets
B) Direct excretion into the bile without modification
C) Conversion into ketone bodies during fasting or low glucose levels
D) Oxidation to generate ATP via the citric acid cycle
E) Packages as TAG into VLDL
B
What is true about NEFA and BMI?
a) Blood NEFA levels are directly proportional to body fat mass
b) Blood NEFA is inversely proportional to BMI
c) Results were inconclusive
d) there is no correlation between BMI and NEFA
D
What is true about NEFA and insulin sensitivity?
a) directly proportional
b) inversely proportional
c) Results were inconclusive
d) there is no correlation between insulin sensitivity and NEFA
b
What is true about NEFA and HGP?
a) directly proportional
b) inversely proportional
c) Results were inconclusive
d) there is no correlation between insulin sensitivity and NEFA
a) directly proportional bc prevents insulin-suppression of glycogenolysis
How do blood NEFA levels change throughout the day?
highest in morning, drop strongly after breakfast, inc gradually during day
HSL is a critical lipase for:
a) adipose tissue glycogenesis
b) VLDL production
c) adipose tissue lipolysis
d) hepatic de novo lipogenesis
c
t/f: Obesity is associated with lower VLDL secretion
false
- most likely due to insulin resistance and bodys attempt to deal with higher NEFA
Which is true:
A) Obesity is associated with decreased VLDL secretion.
B) Obesity is associated with increased VLDL secretion.
C) Obesity prevents the liver from producing VLDL altogether.
D) After a meal, VLDL secretion should increase
E) VLDL production is directly proportional to insulin sensitivity
B
What is not true about insulin resistance
a) results in higher NEFA levels
b) insulin inhibits lipolysis by reducing PKA activity
c) insulin activates PDE
d) PDE causes an increase in cAMP levels
d ) it prevents an increase in cAMP levels
