Module 7: 2nd generation antipsychotics (atypical)

Question 1

Atypical antipsychotics (2nd gen) examples

Answer 1

Olanzapine (zyprexa), quetiapine (Seroquel), Aripiprazole

Question 2

Aripiprazole MOA

Answer 2

serotonin antagonist and partial D2 agonist

Question 3

Clozapine labs

Answer 3

“No blood, no drug”
must check ANC before initiating

*Caution with smokers! increase TAR increase clozapine levels

Question 4

Baseline labs prior to initiation ANY antipsychotic

Answer 4

CBC< CMP, TSH, lipid panel, A1C. prolactin, EKG, urine drug screen, serum pregnancy

Question 5

Rating scales for effectiveness of antipsychotics

Answer 5

Brief psychotic rating scale
Positive and Negative syndrome scale (PANSS)