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HEMA 337 > Module 6: Non-Malignant Leukocyte Disorders > Flashcards

Module 6: Non-Malignant Leukocyte Disorders Flashcards

1
Q

Definition and cause of neutrophilia

A

Neutrophils > 7.5 x 10^9/L

Acute bacterial infection

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2
Q

Definition and cause of neutrophilia

A

Neutrophils > 7.5 x 10^9/L

Acute bacterial infection

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3
Q

Definition and cause of lymphocytosis

A

Lymphocytes > 4.0 x 10^9/L

Acute viral infection

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4
Q

Definition and cause of monocytosis

A

Monocytes >0.8 x 10^9/L

Chronic infection

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5
Q

Definition and causes of eosinophilia

A

> 0.44x 10^9/L

Allergies, parasites, skin diseases

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6
Q

Definition and causes of neutropenia (agranulocytosis)

A
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7
Q

Definition and cause of lymphocytosis

A

Lymphocytes > 4.0 x 10^9/L

Acute viral infection

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8
Q

Definition and cause of monocytosis

A

Monocytes >0.8 x 10^9/L

Chronic infection

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9
Q

Definition and causes of eosinophilia

A

> 0.44x 10^9/L

Allergies, parasites, skin diseases

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10
Q

Definition and causes of basophilia

A

> 0.1 x 10^9/L
Hypersensitivity reactions, colitis, RA, diabetes mellitus
Rare

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11
Q

Definition and causes of neutropenia (agranulocytosis)

A
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12
Q

Definition and causes of neutropenia (agranulocytosis)

A
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13
Q

Definition and causes of lymphocytopenia

A
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14
Q

Description and lab findings of Niemann-Pick disease

A

Enzyme deficiency results in accumulation of sphingomyelin and cholesterol in macrophages
Refractive globules accumulate in cytoplasm of Riemann-Pick in marrow

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15
Q

Description and lab findings of Chediak-Higashi syndrome

A

Defective lysosome membrane fusion proteins result in grossly abnormal granulation
Anemia, abnormal bleeds, endocrine problems, abnormal growth, recurrent infections, die preteens
Characteristic abnormal granulation in granulocytes, lymphs, monocytes in blood and marrow

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16
Q

Description and lab findings of Alder-Reilly anomally

A

Enzyme deficiency results in accumulation of polysaccharides
Mental deficiency and physical deformities
Very prominent and dark azurophil granules

17
Q

Description and lab findings of Pelter-Huet anomaly

A

Hypo segmentation of neutrophils

Look abnormal, function normal

18
Q

Description and lab findings of May-Hegglin anomaly

A

Abnormal bleeding
Doyle like bodies in granulocytes, monocytes, and lymphocytes
Thrombocytopenia and giant platelets

19
Q

Description and lab findings of Gaucher’s disease

A

Enzyme deficiency results in accumulation of glycolipids in macrophages
Big, wrinkled Gaucher cells in bone marrow
Anemia, leukopenia, thrombocytopenia

20
Q

Description and lab findings of Niemann-Pick disease

A

Enzyme deficiency results in accumulation of sphingomyelin and cholesterol in macrophages
Refractive globules accumulate in cytoplasm of Riemann-Pick in marrow

21
Q

Description and lab findings of Chediak-Higashi syndrome

A

Defective lysosome membrane fusion proteins result in grossly abnormal granulation
Anemia, abnormal bleeds, endocrine problems, abnormal growth, recurrent infections, die preteens
Characteristic abnormal granulation in granulocytes, lymphs, monocytes in blood and marrow

22
Q

Description and lab findings of Alder-Reilly anomally

A

Enzyme deficiency results in accumulation of polysaccharides
Mental deficiency and physical deformities
Very prominent and dark azurophil granules

23
Q

Reactive lymphocyte morphology

A

Nucleus - oval, notched, indented or elongated; may be “soft” and intended by adjacent RBCs
Chromatin - irregular, variable clumping and staining intensity, parachromatin more apparent
Nucleoli - 1 or more may be visible, large
Cytoplasm - Increased volume, irregular staining, edges dark and scalloped
May have vacuoles or azurophilic granules

24
Q

Reactive neutrophil morphology

A 
Basophilic cytoplasm
Toxic granulation
Doyle bodies
Vacuolization
Hyper segmentation
25
Q

Lab findings in infectious mononucleosis

A

Increased WBC count
20-97% reactive lymphs, usually absolute lymphocytosis
RBC normal, spherocytes rare
Mild thrombocytopenia in half of cases
Slight increase in serum bilirubin and liver enzymes (mild hepatitis due to EBV)
Positive slide test

26
Q

Define infectious mononucleosis and name the etiological agent

A

Acute viral disease with fever, swollen lymph nodes, absolute reactive lymphocytosis, positive slide test
Caused by Epstein Barr virus

27
Q

Cause and lab findings of whooping cough

A

Bordetella pertussis infection
High WBC, relative and absolute lymphocytosis
RBC and plts normal

28
Q

Cause and lab findings of infectious lymphocytosis

A

Coxsackie A virus or adenovirus
High WBC, relative and absolute normal lymphocytosis
Symptoms like mono, but negative slide test

29
Q

Cause and lab findings of rubella

A

Rubella virus
Lymphocytopenia common
Relative reactive lymphocytosis

30
Q

Cause and lab findings of lupus erythematosus

A

Autoimmune disorder of unknown cause
Pancytopenia common
Indirect fluorescent antibody test for ANA positive

HEMA 337 (7 decks)

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