Module 5 - Part 1

Question 1

Thomas H. Morgan & Lily Vaughan Morgan

Answer 1

Well known for their discovery of X-linkage in fruit flies

Question 2

Alfred H. Sturtevant

Answer 2

Was an undergrad in Morgans lab. He invented gene mapping (tech used to map x-chromo & others)

Question 3

Mendel’s 2nd Law

Answer 3

Law of independent assortment.
Alleles on Dif chromosomes segregate independently from another.

Question 4

CIS

Answer 4

Same colour on same side. (In terms of chromosome and homolog)

Question 5

TRANS

Answer 5

Same colour, opposite side. (In terms of chromosome and homolog)

Question 6

Test cross

Answer 6

A cross between a heterozygous F1 organism & the homozygous recessive parent (P1) organism
- determines the recombinant frequency

Question 7

Recombinant frequency (RF)

Answer 7

The freq. of the recombinant progeny produced by the heterozygous F1

Question 8

RF Formula

Answer 8

of recombinants/ # of recombinants + # of parental

Question 9

How are recombinants generated?

Answer 9

• crossover = chiasma = physical event
• reciprocal exchange of DNA between homologous chromosomes during meiosis
• occurs randomly along the chromosomes

Question 10

What does the frequency of crossovers depend on?

Answer 10

The distance between alleles

Question 11

Nomenclature for genes: AB/ab

Answer 11

• same chromosome
• the two dom alleles are in the CIS conformation

Question 12

Nomenclature for genes: Ab/aB

Answer 12

• same chromosome
• the two dom alleles are in the TRANS conformation