Module 5 Flashcards by Danielle Lencioco

The main components of an empty capsule shell?

Gelatin, Sucrose, and Water

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USP Chapter 797 was introduce in 2004 to provide regulation to pharmacies on quality standards for?

Compounding of sterile product

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USP <800>

Compounding quality nonsterile preparations

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USP <795>

Handling hazardous drugs

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USP <825>

Radiopharmaceuticals

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Starch USP is used in table formulation as

Binder and disintegrant

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Bulk powders include the ff.:

Powder for the tooth sockets
Medicated powder for external use
Nonmedicated powder for external use
Antacid powder

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USP dissolution apparatus 2

Paddle

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USP dissolution apparatus 3

Reciprocating cylinder

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USP dissolution apparatus 4

Flow through cell

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USP dissolution apparatus 1

Basket

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Suppository base that does not dissolve in body fluid

Witepsol base
Wecobee base
Hydrogenated fatty acid of vegetable oils

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Suppository base that do not melt at body temperature but rather dissolve slowly in the body’s fluid

Polyethylene glycol (PEG)

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An equipment which alternatively combine and draw apart the tablet material, as this equipment revolves. Ideal for precise blending of dry-to-dry or dry-to-liquid materials, with short processing times.

Twin blender

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Causes of Bridging in tablets

High coating viscosity
Improper atomization pressure
Poor design of the tablet embossing
Improper application of solution

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Filling-in of the score line or intended logo by the film

Bridging

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What is the percentage (%) of alcohol needed in an alkaline media for it to be an effective preservative?

18%

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What is the percentage (%) of alcohol needed in an acidic media for it to be an effective preservative?

15%

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The plasma concentration time curve obtained by the administration of this preparation exhibit the “PEAK & VALLY”.

Repeat action

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What is the correct order of the steps involved in Sugar-coating?

(1) Water proofing and Sealing
(2) Subcoating
(3) Smoothing and final rounding
(4) Finish and coloring coats
(5) Imprinting, and
(6) Polishing

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Febuxostat is formulated as tablets which is effective in:

Hyperuricemia

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It is any article, other than food, intended to affect the structure or any function of body of both man and animals.

Drug

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The maximum amount of flavoring oil that can be added to a granulation without affecting its tablet characteristics is

0.75%

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The purpose of adding preservatives

(I) To prevent microbial contamination

(II) To add stability to pharmaceutical drugs

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The purpose of methylparaben as a preservatives

For molds

The purpose of propylparaben as a preservatives

For yeast

Forms of water that are suitable for use in parenteral preparations?

(I) Water for Injection, USP | (II) Sterile water for Injection, USP

The following substances may be used as colorants:

Caramel and red ferric oxide

Solid dosage forms in which the medicinal agents and inter substances are enclosed in a small gelatin shell.

Capsules

The following statement about Genacol, is a branded Glucosamine dietary supplement which is formulated as a hard gelatin capsule.

(I) As a dietary supplement, glucosamine is primary used for pain associated with knee osteoarthritis (II) Mild diarrhea, abdominal cramping and nausea were occasionally reported with its consumption (III) Cross-allergenicity in people with shellfish allergies is a concern (IV) Glucosamine sulfate may increase the INR in patients taking warfarin

Imprinted with a mark below the surface

Debossed

Imprinted with a mark raised above the surface

Embossed

Imprinted with a code that is cut into the surface during production

Engraved

Conditions which causes of capping in tablets includes the ff:

(I) When there excessive quantity of fines or powder | (II) When the dies are worn and the punches are imperfect

Following excipients are disintegrators:

Starch | Cellulose

Characteristics of pills

Adhesive and plastic property

Tablets which liquefy when place in tongue

Rapidly disintegrating tablets

Olanzapine is a rapidly disintegrating tablet, the following statements are true:

(I) It belongs under atypical antipsychotic drugs (II) It has a higher affinity for serotonin receptors (III) Side effect is weight gain (IV) Metabolized by the cytochrome p450 system; principally by isozyme 1A2 (CYP1A2)

Hard water contains high amounts of what cations?

Magnesium | Calcium

Tablet processing defect which is caused by the rapid or inadequate solution distribution after each application of coating solution resulting into the roughness of tablet surface is called?

Orange peel

Polyethylene glycol ointment, NF is:

Water soluble base

The following statements are true about levigation:

(I) The levigating agent used should be physically and chemically compatible with the drug and base (II) Mineral oil is used for bases where oils are the external phase (III) It allows reduction of particle size and dispersion of the substance (IV) The amount of levigating agent used should be equal in volume to the solid material to avoid incompatibilities (V) Glycerin is used for bases where water is the external phase

Lipitor is a blockbuster drug. A blockbuster drug generates an annual income revenue of at least:

1 billion US dollars

True or False. Is Zinc chloride is deliquescent?

True

Analgesic is a mixed opioid receptor agonist-antagonist and given at 10 to 20 mg every 4-6 hours

Nalbuphine

USP 41-NF 36 limits what percentage of sulfur dioxide to prevent decomposition of gelatin during the manufacture of hard gelatin capsule:

Not more than 0.1500% based on the latest USP41-BF36

Solid dosage forms, which need to conform to USP 41 disintegration time

(I) Gastro-resistant tablets (II) Effervescent tablets (III) Dispersible tablets

Evidence of physical instability is demonstrated by:

(I) Presence of excessive powder and/or pieces of tablets at the bottom of the container (II) Cracks or capping, chipping in the tablet surfaces or when coating, swelling, mottling, discoloration, fusion between tablets (III) Appearance of crystals on the container walls or on the tablets

Added to render soft gelatin capsule elastic?

Plasticizer (Sorbitol)

Talc in tablet formulation is generally used as

(I) Anti-adherent | (II) Glidant

Diluent of choice when producing tablets through direct compression

Microcrystalline cellulose

Principal bulking agent

Mannitol

Diluent of choice for chewable tablets

Lactose

What tablet processing problem in film coating arises when the fluid delivery rate exceeds the drying capacity of the process?

Picking

The following are true about effervescent tablets:

(I) They are intended to be dissolved or dispersed in water before administration (II) The manufacture of effervescent tablets is carried out in love-humidity conditions (III) The label should state: “Not to be swallowed directly”.

Principal that is/are employed in the use of lubricants in tablet formulations include(s):

(I) Lubricants reduce the dissolution rate (II) Lubricants increase the disintegration time (III) They are added at the very last step prior to compression

Sodium croscarmellose is used primarily in tablet formation as:

Disintegrant

Soft gelatin capsules are usually prepared by the following:

(I) Plate process (II) Reciprocating die process (III) Stern machine

Sour tasting drugs can be formulated with the following as recommended flavors:

(I) Root beer (II) Citrus (III) Cherry (IV) Strawberry

The following statements are true regarding the dry granulation of tablet formulation?

(I) It is also known as double compression (II) Used when the initial powder blend has a significant quantity (III) Used when the active ingredients are sensitive to moisture (IV) Used when the active ingredients are sensitive to elevated temperature

True or False. Is conc. sulfuric acid, sodium nitrate, and potassium nitrate are considered hydroscopic?

True

Methods of preparing effervescent salts:

(I) Fusion | (II) Wet method

The principles of dosage form design and development:

(I) The higher the partition coefficient, the greater is the hydrophobicity of the drug, thus, increasing its permeability to the cell membrane (II) Solubility and dissolution rate are greater for amorphous form than crystalline compounds (III) Polymorphs differ from each other with respect to their physical properties (IV) Q10 is a method of shelf life estimation

The combination components of a running powder used in tablet formulations?

(I) Disintegrants | (II) Lubricants

Clinical uses of Quinidine tablets:

(I) Antiarrhythmic | (II) Antimalaria

The following are kinetic properties of colloids?

(I) Brownian movement (II) Viscosity (III) Sedimentation

Optical property of colloids?

Faraday-Tyndall Effect

This is an international clinical trial to help find an effective treatment for COVID-19, launched by the WHO and partner conutries

Solidarity Trial

Q10 is used for ______ estimation

Shelf-life

Liquid petroleum exhibits a _____ spreading coefficient with water

Negative

Other name of spreading coefficient

Wettability

When the spreading coefficient is _____, oil is expected to spread over water

Positive

A _____ spreading coefficient indicated that oil will not spread over water and the situation where the water is covered by the oil firm is not favourable

Negative

Instrument used to determine freezing point

Beckmann thermometer

Module 5 Flashcards

(74 cards)