Module 5 Flashcards
What is excretion?
Removal of waste products of metabolism from the body
Function of the hepatic artery?
Supplies the liver with oxygenated blood from the heart
Function of the hepatic vein
Takes deoxygenated blood away from the liver
3 ways carbon dioxide is transported around the body
5% in solution in plasma as CO2, 10% combines with amino groups in Hb molecule, 85% hydrogen carbonate ions
Consequences of carbon dioxide not being excreted
Formation of carbaminohaemoglobin which has lower affinity for oxygen than normal haemoglobin
Respiratory acidosis - drop in blood pH, headache, drowsiness, tremors
What blood vessel does the hepatic artery come from?
Aorta
What do lobules make up in the liver?
Lobes
Where does the hepatic vein take dexoygenated blood out of the liver?
Vena cava
What are the specialised epithelial cells in liver lobules called?
Hepatocytes
Adaptation of hepatocytes
Lots of mitochondria, large nuclei for transcription
What is in the centre of a lobule?
Central vein
What are sinusoids?
Large, endothelium-lined spaces that blood passes through
What are Kupffer cells?
They destroy worn out red blood cells, bacteria and foreign matter arriving from digestive tract
Where do central veins in liver lobules lead to?
Hepatic vein
Function of the bile duct in the liver
Takes bile to the gall bladder
What is bile made from and what is it made by?
Made from breakdown of haemoglobin, secreted by hepatocytes
What are bile canaliculi?
Spaces that carry bile to the bile ducts
What is urea produced from?
Excess amino acids containing nitrogen
2 processes that forms urea
Deamination - amino group from each amino acid removed and hydrogen added to make ammonia. The rest of the amino acid is converted to keto acids, and either enters the Krebs cycle or is stored as glycogen.
Ornithine cycle - ammonia converted into urea. CO2 and ammonia converted to carbamoyl phosphate, and eventually water is added to make urea
Process of detoxification of ethanol
Alcohol broken down into acetic acid by alcohol dehydrogenase and aldehyde dehydrogenase, then enters the Krebs cycle