Module 5 Flashcards
An RBC abnormality wherein the RBC is described as having a finger-like or quartz like crystal of dense hemoglobin protruding from the RBC membrane
Hemoglobin SC Crystal
These are RBC inclusions primarily composed of iron which appear as an irregular cluster of small, light to dark blue granules, often near the periphery of the cells when using a wrights stain smear
Appenheimer bodies
Hexagonal crystals of dense hemoglobin formed within RBC membrane
Hemoglobin C crystal
RBC inclusions primarily composed of precipitated RNA which appear as dark blue purple fine or coarse punctate granules distributed throughout cytoplasm when using a supravital stain
Basophilic stippling
During RBC destruction via extravascular hemolysis, hemoglobin from the RBC will be degraded into heme ang globin portion, it removes the iron from heme
Heme oxygenase
During extravascular catabolism of RBC, iron removed from the heme group of hemoglobin will be transported to bone marrow for recycling to be used by developing RBC by
Transferrin
During intravascular catabolism of RBC, unbound hemoglobin that were not reabsorbed in the tubular cells will
Not be excreted in the urine and converted to oxidizied methemoglobin
Intravascular catabolism of RBC, the heme group from methemoglobin will be released in the circulation and be taken up by the transport protein known as
Hemopoxin
Intravascular catabolism of RBC, an excess heme group not eliminated by LRP- CD91 will combine to — forming —- until hemopexin is available for binding
Albumin and methealbumin
In oxygen - hemoglobin dissociation curve, when there is a decreased concentration of carbon monoxide, there is also a decrease in 2-3 DPG, leading to
Increase in Oxygen Affinity
During intravascular catabolism of RBC, hemoglobin released from RBC will be transported to liver for catabolism by
Haptoglobin
During RBC destruction via extravascular hemolysis, hemoglobin from RBC will be degraded into heme and globin portion, the protoporphyrim ring from the heme portion will be open forming the
Intermediate Biliverdin
During RBC destruction via extravascular hemolysis, hemoglobin from RBC will be degraded into heme and globin portion, the intermediate biliverdin from protoporphyrin ring of the heme portion will be converted to unconjugated bilirubin by
Biliverdin Reductase
These are RBCs with a single pointed extension resembling a teardrop or pear
Dacrocyte
Unconjugated bilirubin from thr portal circulation will be transported by albumin going to the liver and be converted into conjugates bilirubin by
Uridine Diphosphate Glucoronyl Transferase
Fragmented RBCs caused by the rupture in the peripheral circulation
Schistocyte
Metabolic shunt generates 2,3 BPG/ 2,3 DPG
Rapoport Luebering Pathway
Hemoglobin iron may become oxidized to Fe by several pathologic mechanisms. What portion of the Embden - Meyerhof pathway reduces iron to fe
Methemoglobin Reductase Pathway
What hexose monophosphate shunt products participate in the detoxification of peroxides
NADPH & Reduced Glutathione
Pathway aerobically generates energy in the form of ATP
Embden Meyerhof Pathway
Well defined hof and a cart wheel like pattern of chromatin are characteristics of
Plasma cells
Auer rods may be seen in
Acute Promyelocyctic Leukemia and Acute Myelomonocyctic Leukemia
Hereditary autosomal dominant condition involves failure of the normal segmentation of the granulocyte nuclei
Pegler huet
Found in the primary granules of neutrophils
Myeloperoxidase
Charcot leyden crystals in secretions can be seen when there is an increase in
Eosinophil
Likely associated with glucocerebroside deficiency
Gauchers disease
Neutrophol metamyelocyte may be best distinguished from neutrophil bands by which criteria
Shape of nucleus
Band cells are
Sausage shaped nucleus
Lipidoses like Gauchers disease involve the
Monocyte
Not a component of Basophil granules
Histaminase
Associated with chediak higashi syndrome except
Inclusions are made of ribosomes
How many percent of neutrophils in the marginating pool
50%
Alder reilly anonaly is an abnormality of
Mucopolysaccharide metabolism
Plasma cell with red to pink cytoplasm is known as
Flame cell
These cells lack the characteristics of mature T and B cells. They participate in antibody dependent cell mediated cytolysis
Null cell
Foam cell is seen in
Niemann pick disease
Variant lf lymphocyte is seen with the fried egg appearance
Type II
Life span of basophils in the blood
60 hrs
Major cytokine responsible for mast cell maturation
Kit Ligand
CD T Cells are also known as cytotoxic T cells, they recognize anyigen presented along with MHC class II molecules
First is true second isfalse
Responsible for maturation of T lymphocytes and regulatoon of their expression of CD 4 and CD8
Thymus
Morphologic changes occur during normal blood cell maturation
Condensation of nuclear chromatin
Product of common lymphoid progenitor cell
B & T lymphocytes
Bone resorbing cells
Osteoclasts
Hematopoietic stem cells produce all lineages of blood cells in sufficient quantities over the lifetime of an individual due to
Are present in large numbers in the bone marrow niches
Organs in hematopoiesis
Liver, spleen, thymus, bone marrow
Thrombopoietin is referred as
MPL Ligand
Primary source of IL 2 are
CD4+ T cells, Natural Killer Cells and B cells
