Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hema Lec > Module 5 > Flashcards

Module 5 Flashcards

1
Q

An RBC abnormality wherein the RBC is described as having a finger-like or quartz like crystal of dense hemoglobin protruding from the RBC membrane

A

Hemoglobin SC Crystal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

These are RBC inclusions primarily composed of iron which appear as an irregular cluster of small, light to dark blue granules, often near the periphery of the cells when using a wrights stain smear

A

Appenheimer bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hexagonal crystals of dense hemoglobin formed within RBC membrane

A

Hemoglobin C crystal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

RBC inclusions primarily composed of precipitated RNA which appear as dark blue purple fine or coarse punctate granules distributed throughout cytoplasm when using a supravital stain

A

Basophilic stippling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

During RBC destruction via extravascular hemolysis, hemoglobin from the RBC will be degraded into heme ang globin portion, it removes the iron from heme

A

Heme oxygenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

During extravascular catabolism of RBC, iron removed from the heme group of hemoglobin will be transported to bone marrow for recycling to be used by developing RBC by

A

Transferrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

During intravascular catabolism of RBC, unbound hemoglobin that were not reabsorbed in the tubular cells will

A

Not be excreted in the urine and converted to oxidizied methemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Intravascular catabolism of RBC, the heme group from methemoglobin will be released in the circulation and be taken up by the transport protein known as

A

Hemopoxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Intravascular catabolism of RBC, an excess heme group not eliminated by LRP- CD91 will combine to — forming —- until hemopexin is available for binding

A

Albumin and methealbumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

In oxygen - hemoglobin dissociation curve, when there is a decreased concentration of carbon monoxide, there is also a decrease in 2-3 DPG, leading to

A

Increase in Oxygen Affinity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

During intravascular catabolism of RBC, hemoglobin released from RBC will be transported to liver for catabolism by

A

Haptoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

During RBC destruction via extravascular hemolysis, hemoglobin from RBC will be degraded into heme and globin portion, the protoporphyrim ring from the heme portion will be open forming the

A

Intermediate Biliverdin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

During RBC destruction via extravascular hemolysis, hemoglobin from RBC will be degraded into heme and globin portion, the intermediate biliverdin from protoporphyrin ring of the heme portion will be converted to unconjugated bilirubin by

A

Biliverdin Reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

These are RBCs with a single pointed extension resembling a teardrop or pear

A

Dacrocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Unconjugated bilirubin from thr portal circulation will be transported by albumin going to the liver and be converted into conjugates bilirubin by

A

Uridine Diphosphate Glucoronyl Transferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Fragmented RBCs caused by the rupture in the peripheral circulation

A

Schistocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Metabolic shunt generates 2,3 BPG/ 2,3 DPG

A

Rapoport Luebering Pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Hemoglobin iron may become oxidized to Fe by several pathologic mechanisms. What portion of the Embden - Meyerhof pathway reduces iron to fe

A

Methemoglobin Reductase Pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What hexose monophosphate shunt products participate in the detoxification of peroxides

A

NADPH & Reduced Glutathione

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Pathway aerobically generates energy in the form of ATP

A

Embden Meyerhof Pathway

21
Q

Well defined hof and a cart wheel like pattern of chromatin are characteristics of

A

Plasma cells

22
Q

Auer rods may be seen in

A

Acute Promyelocyctic Leukemia and Acute Myelomonocyctic Leukemia

23
Q

Hereditary autosomal dominant condition involves failure of the normal segmentation of the granulocyte nuclei

A

Pegler huet

24
Q

Found in the primary granules of neutrophils

A

Myeloperoxidase

25
Q

Charcot leyden crystals in secretions can be seen when there is an increase in

A

Eosinophil

26
Q

Likely associated with glucocerebroside deficiency

A

Gauchers disease

27
Q

Neutrophol metamyelocyte may be best distinguished from neutrophil bands by which criteria

A

Shape of nucleus

28
Q

Band cells are

A

Sausage shaped nucleus

29
Q

Lipidoses like Gauchers disease involve the

A

Monocyte

30
Q

Not a component of Basophil granules

A

Histaminase

31
Q

Associated with chediak higashi syndrome except

A

Inclusions are made of ribosomes

32
Q

How many percent of neutrophils in the marginating pool

A

50%

33
Q

Alder reilly anonaly is an abnormality of

A

Mucopolysaccharide metabolism

34
Q

Plasma cell with red to pink cytoplasm is known as

A

Flame cell

35
Q

These cells lack the characteristics of mature T and B cells. They participate in antibody dependent cell mediated cytolysis

A

Null cell

36
Q

Foam cell is seen in

A

Niemann pick disease

37
Q

Variant lf lymphocyte is seen with the fried egg appearance

A

Type II

38
Q

Life span of basophils in the blood

A

60 hrs

39
Q

Major cytokine responsible for mast cell maturation

A

Kit Ligand

40
Q

CD T Cells are also known as cytotoxic T cells, they recognize anyigen presented along with MHC class II molecules

A

First is true second isfalse

41
Q

Responsible for maturation of T lymphocytes and regulatoon of their expression of CD 4 and CD8

A

Thymus

42
Q

Morphologic changes occur during normal blood cell maturation

A

Condensation of nuclear chromatin

43
Q

Product of common lymphoid progenitor cell

A

B & T lymphocytes

44
Q

Bone resorbing cells

A

Osteoclasts

45
Q

Hematopoietic stem cells produce all lineages of blood cells in sufficient quantities over the lifetime of an individual due to

A

Are present in large numbers in the bone marrow niches

46
Q

Organs in hematopoiesis

A

Liver, spleen, thymus, bone marrow

47
Q

Thrombopoietin is referred as

A

MPL Ligand

48
Q

Primary source of IL 2 are

A

CD4+ T cells, Natural Killer Cells and B cells

Hema Lec (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions