MODULE 4: sensory Flashcards
components of afferent nervous system
Somatic pathway
▪ General : “touch”, proprioception (sense of where body parts are)
▪ Special : vision, hearing, balance
Visceral pathway :
▪ General : nociception, physiological receptors (maintian homeostasis)
▪ Special : olfaction, gustation
neurone classes
- afferent neurons
–> sensory neurons provide environmental information to
the CNS
–> convey info to brain - interneurons
- -> integrate information and formulate a response - efferent neurons
- -> carry instructions from the CNS to the effector organs
receptor adaption: tonic vs phasic
sustained stimulation leads to adaptation of the receptor
tonic –> adapt slowly
e.g. vision, touch
phasic –> adapt rapidly
e.g. some pain receptors
lateral inhibition
increases acuity by dampening neighbouring sensory receptors
receptor types (8)
solute –> work on lock and key design
e.g. taste, smell, neurotransmitter receptors
solvent –> work on pressure or turgidity, i.e. a change in membrane
e.g. mechanical receptors
photoreceptors –> respond to photons via opsins
chemoreceptors –> true lock and key mechanism i.e. respond to specific mechanism
mechanoreceptors –> sensitive to mechanical energy
osmoreceptors –> detect change in concentration in bodily fluids
nociceptors –> pain receptors, similar to high threshold mechanoreceptors
thermoreceptor –> sensitive to heat and cold (and capacin/menthol)
structures in the human eye
Cornea
- transparent i.e. no vascularisation as to not impair vision
- immune privilege i.e. no immune response, takes strong infection to cause disruption
- 5 layers for mechanical protection, epithelium is touch sensitive
- barrier to UV
- most of the refractive power
- sensory receptors for reflexes
- fixed focusing power (because cannot change shape)
Lens
- adaptive focusing power
- no vascularisation
- accommodation (contractive power, close focus = muscle relax)
- UV filter
Retina
- receptor layer
- pigment epithelium at base absorbs light so there is no reflection
- this improves acuity and directionality
Fovea
- best focus, allows us to see fine details
- sits inside macula
- 1 photoreceptor / ganglion cell in macula –> no overlap in receptive fields –> discern fine details
Optic Disc
- where nerves exit
- “blind spot”
- vision of other eye compensates
refraction in the human eye
- when light hits boundary between two mediums, light bends
- eye contains mediums with different refractive index
- light changes direction when entering eye
- increases sensitivity of eye i.e. able to focus on different things by changing RI of lens
photoreceptors
inner segment:
- nucleus & mitochondria
outer segment:
- membrane stacking
- in cone, membrane folds
- in rod, free floating discs
IPRGC:
- intrinsically photosensitive retinal ganglion cells
- don’t need photoreceptors to measure amount of light
- contain melanopsin which allows them to complete photo-transduction
- involved in reflex
Rods • 120 millions / retina • High sensitivity • Low acuity • More pigments • Achromatic and night vision
Cones • 6 millions / retina • Low sensitivity • High acuity • Three pigment types • Chromatic vision
adaption to darkness - rods and cones
cones adapt to low light very quickly
cones do not provide effective vision in darkness
rods can adapt to much lower levels of light, but takes longer
colour vision
we can see colour because the eye contains different pigments each with different absorbance
i.e. different peaks of optimal detection
the ratio is what is important wavelengths and intensity confounded because photoreceptor alone cannot direction based on these S -M - L --> green : 0% – 100% – 80% --> blue: 55%–45%–35% --> orange : 0% – 20% – 60%
phototransduction in rods
1) light photon enters eye and hits retina.
2) photons change retinal from cis to trans conformation
3) photon activates transducins
4) transducins release alpha subunit which connects to phosphodiesterases
5) phosphodiesterase turns cyclic GMP to GMP which amplifies signal
6) when cGMP concentration lowers, unselective cation channels close
7) MP in rods hyperpolarises (base state is depolarised, more intense light = more hyperpolarisation)
8) hyperpolarisationg closes VG calcium channel
THESE STEPS ARE DESIGNED TO AMPLIFY SIGNAL
easy to control pathway at each step
retinal circuit
- diagram*
1. photoreceptors hyperpolarise (don’t release neurotransmitters)
- horizontal cells hyperpolarise
- –> connect to bipolar cells via gap junctions
- –> very fast connection - bipolar cells hyperpolarise
- –> connect photoreceptors to ganglion cells
- –> can connect one to one or multiple photoreceptors to one ganglion - ganglion cells produce AP and project to brain
info goes vertically (photoreceptor to ganglion cells)
info also goes horizontally —> detects all features in vision
retina cell types: horizontal cells
horizontal cells sit in between photoreceptors and bipolar cells
connect via gap junctions
cover large area of retina i.e. cover receptive field of large number of photoreceptors
horizontal cells estimate average intensity across many receptive fields
work via lateral inhibition
retina cell types: bipolar cells
connect photoreceptors and ganglion cells
hyperpolarised = off bipolar cell:
convert light energy into inhibition i.e. see light and stop actions potentials
depolarised = on bipolar cell:
see light and have action potential
1-20 photoreceptors connect to 1 bipolar cell
many different sub-types
e. g. midget bipolar cells
- in fovea
- important for high acquity
retina cell types: amacrine cells
connect with bipolar cells and retinal ganglion cell
similar to horizontal cells in organisation, but have many more sub-types (classified by dendrite field)
wise connection range = GABA
narrow connection range = glycine
integrates information horizontally
creates local subunits (bipolar cells + ganglion) that encode one feature e.g. detect motion, detect colour vision, etc
