Module 3: Ulcerative Colitis Dr. Covert Flashcards
Dr. Covert EXAM V
Which drug covers all areas of the GI?
Pentasa
Drug that covers Jejenum and ileum?
Pentasa
Drug that covers the terminal ileum?
Asacol
Pentasa
Drug covering the proximal colon?
Apriso, balsalazide, Lialda, olsalazine, Delzicol
Asacol
Pentasa
Drugs covering the distal colon?
Mesalamine enema or steroid enema
Apriso, balsalazide, Lialda, olsalazine, Delzicol
Asacol
Pentasa
Drugs covering the rectum
Mesalamine supp.
Mesalamine enema or steroid enema
Apriso, balsalazide, Lialda, olsalazine, Delzicol
Asacol
Pentasa
Which meds to use to bridge a patient maintenance therapy?
Steroids
systemic: 40-60 mg prednisone
topical: Budesonide: mild or moderate DC or UC
What are the topical steroids?
Entocort EC: capsule
Uceris: rectal foam
What is the TNF inhibitor used only in UC?
Golimumab (Simponi)
What is the TNF inhibitor used only in CD?
Certolizumab (Cimzia)
What is the Integrin receptor antagonist used in UC?
Vedolizumab (Entyvio)
also in CD
What is the Integrase receptor antagonist only used in DC?
Natalizumab (Tysabri)
Ustekinumab (Stelara)
What is the JAK inhibitor approved for UC?
Tofacitinib (Xaljanz)
-oral 10 mg PO BID
-for patients with UC refractory to other biologics
-ADR: URTI, h/a
Immunomodulators for UC
Thiopurine (also in Crohn’s disease)
ADR: bone marrow suppression, hepatoxicity
Drugs for patients very Refractory to UC
Cyclosporine (calcineurin inhibitor), is not often used
-ADR: nephrotoxicity, HTN, hyperglycemia/DM, gingival hyperplasia, hirsutism
-IV only as rescue therapy in fulminant UC
-change to vedolizumab when remission is maintained
