Module 3: PK & PD - Why should you care?

Question 1

Joe is taking a prodrug called “Cat” to manage his hypertension. What would you expect to see in terms of Cat’s effect on Joe’s blood pressure if liver enzymes fail to metabolise this drug?

a. Joe’s blood pressure will remain high
b. Joe’s blood pressure will drop significantly.
c. Joe’s blood pressure will increase further.
d. Joe’s blood pressure will likely decrease if the dose of a prodrug is increased.

Answer 1

a. Joe’s blood pressure will remain high.

Question 2

Which of the following polymorphisms can predict responsiveness to antidepressants?

a. Ion channel polymorphisms.
b. 5-HT receptor polymorphisms.
c. Genetic polymorphisms in the CYP2C19.
d. Beta-adrenergic receptor polymorphisms.

Answer 2

b. 5-HT receptor polymorphisms.