MODULE 3 (DISPENSING) Flashcards
Drugs bound to plasma proteins are considered:a. pharmacologically activeb. pharmacologically inactivec. free drugsd. bioavailable drugs
pharmacologically inactive
Alkaline salts like potassium penicillin when placed in an acidic solution can result in:a. conversion into free acidb. precipitation of penicillinc. insolubilityd. all of the above
all of the above
In metabolizing a standard dose of INH, Filipinos are considered:a. fast acetylatorsb. slow acetylatorsc. neither slow or fastd. same as the Caucasians
fast acetylators
The following are true regarding incompatibilities except:a. problems arising during compounding, dispensing and dispensing and drug administrationb. easier to correct than to preventc. may be intentional or unintentionald. must be recognized by pharmacists
easier to correct than to prevent
The following are guidelines for reducing drug interactions, except:a. employ combination therapyb. identify patient risk factorsc. educate the patientd. know properties of drugs
employ combination therapy
Enzyme inhibition of coumarins can lead to:a. hypoglycemiab. profuse bleedingc. blood clottingd. convulsion
profuse bleeding
Anaphylaxis is a:a. Type A ADRb. Type B ADRc. Type E ADRd. Type F ADR
Type B ADR
Oxidizing agents are incompatible with reducing agents. This is a:a. physical incompatabilityb. chemical incompatibilityc. therapeutic incompatibilityd. both A &B
chemical incompatibility
Any drug reaction which does not necessarily have a causal relationship with the treatment is called an:a. adverse drug reactionb. therapeutic incompatibilityc. adverse drug eventd. none of the above
adverse drug reaction
Teratogenicity is a/an:a. Type A ADRb. Type B ADRc. Type C ADRd. Type D ADR
Type D ADR
The following are true about biotransformation except:a. occurs after drug distributionb. converts polar to nonpolar drugsc. converts lipophilic to hydrophilic drugsd. can influence drug elimination rate
converts polar to nonpolar drugs
The following are manifestations of chemical incompatibilities except:a. immiscibilityb. photolysisc. gel formationd. evolution of gas
immiscibility
The precipitation of an organic substance from a saturated solution when highly soluble salts are added is known as:a. polymorphismb. salting-outc. racemizationd. eutexia
salting-out
Acacia in the presence of Bismuth salts can form a “cake” at the bottom of the container. This manifestation is known as:a. gelatinizationb. hydrolysisc. emulsificationd. cementation
cementation
Sudden withdrawal of steroids can result in:a. anemiab. hypertensionc. Parkinson’s diseased. addison’s disease
addison’s disease
A mathematical model for a potentiating drug effect:a. 1 + 1 = 2b. 1 + 1 = 3c. 0 + 1 = 2d. 1 + 1 = 0
0 + 1 = 2Note: Potentiation: when one drug does not elicit a response on its own but enhances the response to another drug.
A remedy for tablet granulations containing vitamin C:a. prepare by dry granulationb. use precoated ascorbic acid granulesc. both A & Bd. none of the above
both A & B
Chloramphenicol palmitate exists in 3 different polymorphs, each differ in the ff. properties, except:a. solubilityb. free energyc. melting pointd. none of the above
none of the above
The following are the physiologic effects of food on drug reaction, except:a. reducing gastric emptying rateb. milk reduces absorption of tetracyclinec. tea increases absortion of paracetamold. vegetables potentiate anticoagulants
vegetables potentiate anticoagulantsNote: Vitamin K (w/c is high in leafy vegetables) helps to make various proteins that are needed for blood clotting
Important characteristics of idiosyncratic drug reaction, except:a. congenital hypersensitivitiesb. genetic or hereditary in originc. metabolic abnormalityd. none of the above
none of the above
Monoamine oxidase inhibitors (MAO inhibitors) and foods rich in tyramine like cheese will lead to:a. accumulation of pressor aminesb. increase in blood pressurec. non-metabolism of tyramined. all of the above
all of the above
The following condition/s will amplify the activity of cardiac glycosides:a. hypercalcemiab. hypokalemiac. both a & bd. none of the above
both a & b
Drug-drug interactions that occur when one drug alters the absorption, distribution, metabolism, and excretion ofthe other drug.a. pharmacokinetic interactions b. pharmacologic interactionsc. pharmacodynamic interactiond. all of the above
pharmacokinetic interactionsNote: Pharmacokinetics is the study of how the body interacts with administered substances for the entire duration of exposure
Displacement of a plasma-protein bound drug such as in Warfarin-phenylbutazone interaction, results in:a. hemorrhage b. increase concentration of warfarinc. decreased activity of warfarind. both A & B
both A & B
Tobacco and cigarettes are potent enzyme inducers. As a consequence,a. one needs to increase dose of drug b. this leads to drug tolerancec. this is an ADRd. all of the above
all of the above
A drug-induced hypersensitivity reaction caused by sulfonamides:a. Parkinson’s disease b. Steven’s Johnson syndromec. hypertensiond. contact dermatitis
Steven’s Johnson syndromeNote: a rare, serious disorder of the skin and mucous membranes. It’s usually a reaction to medication that starts with flu-like symptoms, followed by a painful rash that spreads and blisters.
The following are true regarding excretion of acidic drugs except:a. exist in the ionized state in alkaline urineb. exist in the non-ionized form in acidic urinec. acidic urine increases drug actiond. none of the above
none of the above
Phenobarbital and griseofulvin are __________of coumarins.a. enzyme inducers b. enzyme inhibitorsc. antagonistsd. agonists
enzyme inducers
Type F ADRs can occur as a result of the following except:a. antimicrobial drug resistance b. patient compliancec. counterfeit drugsd. drug instability
Patient complianceNote:Type F = unexpected Failure of therapy. - refers to the undesired effects of ceasing the drug
Chloramphenicol can lead to this untoward drug reaction:a. agranucytosisb. Gray syndromec. both A & Bd. none of the above
both A & B
A fever response to antibiotic therapy caused by the sudden release of endotoxins from various killed microorganisms is called:a. Herxheimer reaction b. Lyell’s syndromec. skin reactiond. anaphylactic reaction
Herxheimer reaction
Camphor, menthol, acetophenetidine, phenol will form:a. eutectic combinationb. liquefactionc. explosive combinationd. both A & B
eutectic combination
The manifestation in no. 32 is a result of a:a. therapeutic incompatibilityb. chemical incompatibilityc. physical incompatibilityd. adverse drug reaction
therapeutic incompatibility
The most important protein to which drugs can bind in the plasma:a. lipoprotein b. albuminc. glycoproteind. none of the above
albumin
Side effects of streptomycin:a. headache b. dryness of the mouthc. ototoxicityd. none of the above
ototoxicity
The following is/are true regarding absorption of salicylic acid:a. non-ionized form is more lipid-soluble & absorbableb. ionized form is more lipid-soluble & absorbablec. polar form is more readily absorbedd. absorption is increased when taken with an antacid
non-ionized form is more lipid-soluble & absorbable
UV light-sensitive substances are best protected using:a. amber bottleb. plastic containerc. flint glassd. carton box
amber bottle
Oxidation is:a. loss of electrons b. dehydrogenationc. cause of drug instabilityd. all of the above
all of the above
The transport of a substance from one part of the body to another by means of blood:a. absorption b. distributionc. metabolismd. excretion
distribution
The following are possible remedies for liquefaction of solid substances except:a. triturate separately and mix by tumblingb. add adsorbents to liquid combinationc. dispense powders separatelyd. incorporate cotton in packaging
incorporate cotton in packaging
The following type/s of incompatibility may be dispensed:a. intentional incompatabilityb. unintentional incompatabilityc. delayed chemical incomp., but within shelf-life of productd. both A & C
both A & C
The conversion of an optically active form to an optically inactive form is called:a. polymorphism b. racemizationc. polymerizationd. enantiomorphism
racemization
Precipitation can be:a. physical incompatibility b. chemical incompatabilityc. adverse drug reactiond. A or B
A or B
Examples of co-solvents:a. water, butanolb. alcohol, mineral oilc. glycols, sorbitol, glycerold. acetone, water, alcohol
glycols, sorbitol, glycerol
Enzyme induction of Phenobarbital with oral contraceptives can lead to:a. decreased Phenobarbital action b. increased oral contraceptives actionc. unreliable contraceptiond. none of the above
unreliable contraception
Characterizes the first exposure of the fraction of the drug metabolized in the liver:a. first pass effect b. drug-receptorinteractionc. biotransformationd. pharmacokinetics
first pass effect
These are functions of a pharmacist except:a. rug information b. diagnosisc. counseling on medicationsd. monitor drug response
diagnosis
A physiological or a psychological state resulting from drug administrationa. drug dependenceb. drug habituationc. drug addictiond. drug tolerance
drug dependence
An ADR experienced as a consequence of receiving an inappropriately high dose of the drug due to patientcharacteristics:a. idiosyncracyb. extension effectc. side effectd. Type B
extension effect
The ff. is/are characteristic/s of side effects:a. dose-dependent b. predictablec. associated pharmacological effectd. all of the above
all of the above
Oral antihistamines exhibit the following side effect:a. drowsinessb. sleepinessc. both A & Bd. anemia
both A & B
Prescriber of a prescription:a. pharmacistb. veterinarianc. nursed. medical technologist
veterinarian
Compounding is concerned with:a. supply of a medicineb. preparation & distribution of drugsc. order for medicined. preparation of medicine
preparation of medicine
The supply of medicine to an individual patient in accordance to the prescription given by the physician:a. compoundingb. formulationc. dispensingd. none of the above
dispensing
A prescription should be refused when:a. patient is terribly sickb. there is no available delivery servicec. essential information is missingd. it is not signed by the pharmacist
essential information is missing
An example of a subscription:a. M. ft. sol. b. 1 tab q 6 hrsc. shake well before usingd. 250 mg capsule
M. ft. sol.
A filled prescription for ethical drugs must be:a. returned to the patientb. filed for future referencec. discarded after recordingd. forwarded to BFAD
filed for future reference
Which of these drug products require a physician’s prescription?a. Aspirin 325 mg tab b. Paracetamol 500 mg Tabc. Nubain 10 mg/viald. both B & C
both B & C
Which of the ff. correctly applies to this group of drug products? Paracetamol 325 mg. Tab, Cortal 325 mg Tab,Alvedon 325 mg Taba. all are generically equivalentb. all are in brand namesc. all are non-prescription drugsd. all are prescription drugs
all are non-prescription drugs
Because it is the language of medical science throughout the world, this language is still used in Rx writing:a. Englishb. Germanc. Latind. Spanish
Latin
The prescription should be read and checked:a. infront of the patient/customerb. in the privacy of the pharmacyc. in the counter of the boticad. none of the above
in the privacy of the pharmacy
For dispensing thick viscous liquids, the container should be:a. standard prescriptionb. wide-mouthed bottlesc. collapsible tubesd. dropper bottles
wide-mouthed bottles
When the generic name is preceded by the brand name, the prescription is:a. erroneous prescriptionb. violative prescriptionc. impossible prescriptiond. none of the above
erroneous prescription
Generic dispensing means:a. dispensing drugs with generic names onlyb. dispensing with correct prescriptionc. dispensing the customer’s choice from generally equivalent drugsd. dispensing drugs in proper containers
dispensing the customer’s choice from generally equivalent drugs
When dispensing a compounded prescription, these information must be written on the label except:a. indicationsb. name and strength of actives c. name of manufacturerd. name of physician
name of physician
In a prescription, the dispensing directions to the pharmacist is the:a. superscriptionb. subscriptionc. inscriptiond. signa
subscription
How many mL will you dispense for a prescription calling for a 100 g of a liquid substance with a sp.gr. of 1.25?a. 75 mL b. 80 mLc. 85 mLd. 90 mL
80 mL
Providing the correct medicines at the right time at the right dose and using the right route of administration to theright patient is:a. primary careb. rational drug therapyc. osteopathyd. homeopathy
rational drug therapy
The following are true about dimercaprol except:a. British Anti-Lewisite b. Indicated for Fe poisoningc. indicated for as poisoningd. chemical antagonist
Indicated for Fe poisoning
Identify the odd-man-out:a. complete formation b. insolubilityc. liquefaction of solid ingredientsd. polymorphism
complete formation
Group of drugs commonly abused by athletes:a. anabolic steroidsb. dexamethasonec. antibioticsd. vitamins
anabolic steroids
Immediate remedy for anaphylaxis:a. epinephrine injection b. aspirinc. antihistamined. antibiotic
epinephrine injection
A drug whose action is affected in a drug interaction:a. precipitant b. object drugc. interactantd. none of the above
object drug
The following are remedies for oxidation except:a. acid pH b. change dosage formc. addition of antioxidantd. protection from light
acid pH
A suspension with the f. ingredients (FeCl3, Fe(OH)3, acacia, FD&C #5 (orange color) and methyl paraben will reveal this manifestation:a. polymerization b. gelatinizationc. cementationd. precipitation
gelatinization
The following are patient-related predisposing factors to ADRs except:a. age b. formulationc. genetic dispositiond. history of allergy
formulation
Probenecid and penicillin exhibits this type of interaction:a. enzyme induction b. enzyme inhibitionc. alteration in gastric emptyingd. competition for tubular secretion
competition for tubular secretion
Citric acid, atropine sulfate and ferrous sulfate are classified as:a. eutectic mixtures b. deliquescent substancesc. efflorescent substancesd. polymorphs
efflorescent substances
A mathematical model for synergism:a. 1 + 1 = 2 b. 1 + 1 = 8c. 0 + 1 = 2d. 1 + 1 = 0
1 + 1 = 8
Term for migration of the drug into the container:a. sorption b. leachingc. permeationd. vaporization
sorption
The conversion of an optically active drug with one chiral center into an optically inactive isomer:a. polymorphism b. enatiomerismc. epimerizationd. racemization
racemization
One of the violations committed by dispensing pharmacist is:a. informing the patient of the current list of available drugsb. imposing a particular brand or product on the buyerc. recording of prescriptions filledd. dispensing of the product according to the prescription
imposing a particular brand or product on the buyer
An impossible prescription is described by the following except:a. only the generic name is written but not legibleb. both generic & brand names are not legiblec. the generic name does not correspond to the brand named. the generic name is not legible and the brand is written legibly
the generic name is not legible and the brand is written legibly
The incorrect prescription that can be filled is the:a. impossible prescription b. erroneous prescriptionc. violative prescriptiond. none of the above
erroneous prescription
The date after which the product is not intended to be used:a. beyond-use date b. expiry datec. stop dated. both A & B
both A & B
The following are importance of recognizing potential incompatibilities, except:a. rewarding for the pharmacist b. savings in money, time effortc. safety o the patientd. quality medicines dispensed
rewarding for the pharmacist
Poor patient compliance with prescription instruction is usually due to the ff. except:a. patient understood pharmacists instructions poorlyb. pharmacist has poor communication skillsc. inadequate time of pharmacist for patient counselingd. any of the above
any of the above
HLB is a system used to distinguish between:a. surfactants b. glidants c. suspending agentsd. excipientse. disintegrators
surfactants
The purpose of the prescription number is:a. to identify the prescription for future referenceb. as a substitute for the name of the drugc. to guide the pharmacist in costingd. to provide professional fee to the medicine
to identify the prescription for future reference
In pricing the prescription, the pharmacist must consider:a. cost of ingredients b. professional feec. percentage mark-upd. all of the above
all of the above
If there is doubt in legibility of the prescription, the pharmacist should:a. decide based on patient’s ailment b. make an educated guessc. consult the prescriberd. consult MIMS
consult the prescriber
For the guidance of the patient, the prescription needs:a. signa b. subscriptionc. superscriptiond. inscription
signa
Importance of a label:a. for sake of art b. to establish identityc. to improve eleganced. to give prominence
to establish identity
An auxiliary label except:a. do not repeat b. for external usec. shake well before usingd. ophthalmic use
do not repeat
Refers to the schedule of dosing (e.g., QID, 10 days)a. divided doses b. dosage regimenc. single dosed. total dose
dosage regimen
When dispensing prepared dosage forms, the pharmacist may use which of the ff. dose equivalents?a. exact equivalentb. exact dosec. approximate dosed. a and b
a and b
Indicates the quantitative range or amounts of drug that maybe prescribed within the guidelines of usual medical practice.a. divided dose b. usual dosage rangec. loading dosed. total dose
usual dosage range
Which of the following dose not cause a therapeutic incompatibility?a. errors in pricing b. dosage form errorsc. loading dosed. errors of storage and supply
errors in pricing
An associated pharmacological effect of chlorphenamine maleate:a. hypotensionb. sedationc. headached. nausea
sedation
Ecstacy exhibits this type of ADR:a. Type Ab. Type Bc. Type Cd. Type D
Type C
Idiosyncratic reactions are considered:a. Type A ADR b. Type B ADRc. Type C ADRd. Type E ADR
Type B ADR
An anionic exchange resin intended to bind bile acids, cholesterol metabolites and co-administered drugs:a. chloramphenicol b. cholesterol precursorc. tetracyclined. colestyramine
colestyramine
Are added to drug formulations to prevent or reduce oxidationa. complexing agents b. surfactantsc. antioxidantsd. additives
antioxidants
This container is impervious to air and other gases under ordinary conditions of handling storage and transport:a. airtight container b. security closedc. hermitically sealedd. child-resistant container
hermitically sealed