Module 2 - Pharmacokinectics

Question 1

Definition - It is the pH at which the drug will exist in solution at 50% ionized and 50% non-ionized.

Answer 1

pKa

Question 2

This constant determines how a drug will act in the body. It is the ionization constant of a chemical compound.

Answer 2

pKa

Question 3

If pH - pKa = 0 the ratio equals 50%
If pH - pKa = 0.5 the ratio equals 75/25 %
If pH - pKa = 1 the ratio equals 99/1 %

Answer 3

This is the first step used to determine the extent of ionization

Question 4

A drug that is completely non-ionized is water soluble or lipid soluble.

Answer 4

Lipid soluable

Question 5

For Bases
If pH > pKa non-ionized predominates
If pH = pKa non-ionized = ionized
If pH < pKa ionized predominates

Answer 5

Level of ionization for Bases

Question 6

For Acids:
If pH > pKa ionized predominates
If pH = pka ionized = non-ionized
If pH < pKa non-ionized predominates

Answer 6

Level of ionization for Acids

Question 7

For Acidic Drugs:
pH-pKa<0, nonionized
pH-pKa >0, ionized

Answer 7

Ionization for Acidic Drugs

Question 8

For Basic Drugs:
pKa - pH <0, nonionized
pKa - pH > 0, ionized

Answer 8

Ionization for Basic Drugs

Question 9

The pH of Gastric Juice

Answer 9

pH = 1.0-3.0

Question 10

The pH of Small intestines: duodenum

Answer 10

pH = 5.0-6.0

Question 11

The pH of Small Intestines: ileum

Answer 11

pH = 8

Question 12

The pH of the Large Intestines

Answer 12

pH = 8

Question 13

The pH of Plasma

Answer 13

pH = 7.4

Question 14

The pH of CSF

Answer 14

pH = 7.3

Question 15

The pH of Urine

Answer 15

4.0-8.0