Module 2 Key Terms Flashcards
cell possessing properties of fibroblasts and smooth muscle cells that cause wound contraction
myofibroblast
final phase of wound healing during which collagen matures and reorients along the liens of stress
maturation/remodeling
proteases that degrade the extracellular matrix
matrix metalloproteases (MMPs)
cell that helps initiate inflammation; secretes histamine, enzymes, and chemical mediators
mast cell
when PMNs are pushed to the sides of a vessel wall
margination
scar due to the overproduction of collagen that extends beyond the confines of the original wound
keloid
cell surface receptors that allow cells to reversibly bind to the extracellular matrix
integrins
first phase of wound healing, characterized by localized redness, heat, swelling, pain, decreased function
inflammation
a pothole-type wound that fails to build a sufficient granulation matrix
hypo granular
overproduction of collagen that stays within the confines of the original wound
hypertrophic scarring
error of the proliferative phase in which too much granulation tissue is formed and epithelialization is delayed
hypergranulation
a closed wound with tissue strength approachign normal
healed wound
temporary structure composed of vascularized connective tissue that fills the wound void
granulation tissue
dermal cells that produces collage, elastin, granulation tissue, and growth factors
fibroblast
mixture of fluid, high levels of protein, and cells
exudate
process by which keratinocytes resurface the wound defect
epithelialization
keratinocyte migration over the lip or margins of the dermis
epibole
the movement of PMNs through capillary walls
diapedesis
a combination of primary and secondary wound healing processes in which the wound is first observed before primary closure
delayed primary closure
separation of wound margins
dehiscence
substance that is poisonous to human cells
cytotoxic agents
signaling protein during the inflammatory phase of wound healing
cytokine
local change of polarity at the site of integumentary injury
current injury
pathological shortening of scar tissue resulting in a deformity
contracture
enzyme that breaks down collagen
collagenase
a wound in which the epithelial integrity has been restored
closed wound
movement along a chemical gradient
chemotaxis
substance that attracts cells
chemotactic agents
formation of new blodo vevssels
angiogenesis
endothelial cell that lines vessle walls
angioblasts
wound caused by scraping or friction to the skin’s surface
abrasion
process by which myofibroblasts pull wound margins closer together, thereby decreasing the size of the defect
wound contraction
proteases that regulate the activity of MMPs
tissue inhibitors of matrix metalloproteases (TIMPS)
wound healing process in which granulation tissue is formed to fill the wound defect
secondary closure
a substance released by injured cells that cause vasodilation
prostaglandin
second phase of wound healing; building and regenerating phase consisting of angiogenesis, granulation tissue, formulation, wound, contraction, and epithelialization
proliferation
process by which wounds heal if the wound margins can be approximated
primary closure
cell that cleans the wound; secretes enzymes and inflammatory mediators
polymorphonuclear
cell that helps control beeling; releases growth factors and chemotactic agents
platelet
growth-promoting substance that increases or enhances cell size, proliferation, or activity
growth factor
collection of necrotic cells, fibrin, collagen, and platelets that cover a superficial wound
scab
cell that directs the repair process, secretes growth factors and enzymes, and destroys bacteria and debris
macrophage
