Module 2- Administering IV Medications Flashcards
what is hypersensitivity?
reflection of excessive or aberrant immune response to any type of stimulus
how many reactions are there for H? and which ones are usually allergic rxns?
classified into 4 types of reactions (most allergic reactions are either T1 or 4)
what is the most severe H?
anaphylaxis (type 1)
what are the S+S of anaphylactic H?
edema in many tissues, hypotension, bronchospasm, and cardiovascular collapse (severe cases)
when does the immediate anaphylaxis rxn start?
in minutes of exposure to antigen
which ab is involved?
IgE
anaphylaxis can be what?
local or systemic
what are examples of T1 H?
allergic rhinitis, asthma, severe allergic response in people allergic to penicillin or latex
what is type 2 H and describe it with the type of Ab’s
Cytotoxic H. this is when the immune system mistakenly identifies a normal constituent of the body as foreign. IgG or IgM
what is/describe T3 H and the type of Ab’s
Immune Complex H where IC are formed when Ag’s bind to Ab’s. they deposit in tissues on endothelium and cause injury
what is the most common cause of anaphylaxis?
penicillin
what is a good indicator of the severity of allergic rxn?
time from exposure to the antigen to onset of symptoms: the faster the onset, the more serious the reaction
the severity of previous reactions does not what?
does not determine the severity of subsequent reactions, it could be the same, or more or less severe
what are the mild reaction symptoms and when does this begin
consist of peripheral tingling and sensation of warmth, possibly accompanied by sensation of fullness in mouth and throat
○ Begins in 2 hours of exposure
what are the moderate reaction symptoms and when does this begin
• Moderate reactions may include flushing, warmth, anxiety, itching in addition to any of the milder symptoms
○ More serious include bronchospasm and edema of airways or larynx with dyspnea, cough and wheezing
-Onset is 2 hours as well
what are the symptoms for a severe systemic reaction?
• Severe systemic reactions have an abrupt onset with same S+S described previously
-Symptoms progress rapidly to bronchospasm, laryngeal edema, severe dyspnea, cyanosis, and hypotension
what might an insulin allergic patient with diabetes and those allergic to penicillin need?
desensitization
what is desensitization
based on controlled anaphylaxis, with a gradual release of mediators
what should those who undergo desensitization be aware of?
are cautioned that there should be no lapses in therapy because this may lead to the reappearance of the allergic reaction when the medication is resumed
what is the medical management for anaphy.?
depends on severity of reaction.
- epinephrine
- antihistamines, corticosteroids
- IV fluids, volume expanders, vasopressor agents are administered to maintain BP
how long are those who suffered severe reactions monitoring for?
12-14 hours
what is anaphylactic shock?
• Occurs rapidly and is life-threatening
-Because anaphylactic shock occurs in patients already exposed to an antigen and who have developed antibodies to it, it can often be prevented
how is anaphylactic shock caused?
• Caused by severe allergic reaction when patients who have already produced antibodies to a foreign substance (antigen) develop a systemic antigen-antibody reaction
S+S of anaphylactic shock
• Commonly show signs of respiratory distress (wheezing, stridor), hypotension d/t vasodilation, and cardiovascular changes and neurologic compromise in addition to a wide variety of other potential S+S
• Angioedema: lips/tongue swelling or eyes/trachea
-Normally you see a increase in HR with a decrease in BP, and then go bradycardic