Module 2

Question 1

Which modality is a possibility for local treatment of prostate cancer?

Answer 1

Radical prostatectomy

Question 2

For what type of patient is observation, or watching waiting an option?

Answer 2

Patients who have a life expectancy of < 5 years

Question 3

What is defined as 2 consecutive rising PSA values >.2ng/ml, PSA rising after radical prostatectomy, or any PSA increase > 2ng/ml higher than the nadir?

Answer 3

Biochemical relapse

Question 4

Which type of provider is most involved in treating and directing treatment of prostate cancer at later stages?

Answer 4

Oncologist

Question 5

Which of the following is NOT considered an ADT?

Answer 5

Radium 223 (Zofigo)

Question 6

Albiraterone acetate (Zytiga)is indicated for patients with what type of prostate cancer

Answer 6

(A and B) Metastatic castration resistant/Metastatic high-risk castration sensitive

Question 7

How does denosumab (Prolix and Xgeva) inhibit osteoclasts and subsequently inhibit their roles in bone resorption?

Answer 7

Binds to the receptor activator of nuclear factor kappa B ligand (RANKL)

Question 8

Which of these agents is currently FDA approved for marketing in the United States for non metastatic castration resistant prostate cancer?

Answer 8

Apalutamide (Erleada)

Question 9

The androgen receptor splice variant 7 (AR-V7) is associated with resistance to which treatment?

Answer 9

Abiraterone acetate (Zytiga) and enzatutamide (Xtandi)

Question 10

For which patients did enzalutamide improve overall survival?

Answer 10

(D all) those who received prior docetaxel based chemo w/ metastatic CRPC, chemo naive patients with metastatic CRPC and those with non-metastatic CRPC

Question 11

Which chemotherapy agent is typically used first?

Answer 11

Doctaxel (Taxotere)

Question 12

Which treatment resulted in fewer skeletal related events in patients with documented bone metastasis and prostate cancer that had progressed after treatment with at least one hormonal therapy compared with treatment with placebo?

Answer 12

Zoledronic acid (Zometa)