MODULE 2 Flashcards
Consider drugs in body to be in DYNAMIC STATE
Pharmacokinetic model
Important tool for analyzing drug movement quantitatively
Calculus
Used to relate the concentrations of drugs in various body organs
Differential equation
Frequently used to model the cumulative therapeutic or toxic responses of drugs
Integrated equation
Branch of calculus that involves finding the rate at which a variable
quantity is changing
Differential calculus
Reverse of differentiation
Integration
Summing up of small individual pieces under the graph
Integration process
Sum of individual areas under the graph
Definite Integral
Numerical method used in pcok to calculate AUC
Trapezoidal rule
Important method of visualizing relationship between variables.
Graph
Placed horizontal line or in abscissa (x axis)
Independent variable
Placed vertically or in ordinate (y axis)
Dependent variable
An independent variable plotted on abscissa
Time
Arranged vertically or logarithmically from left to right or bottom to top.
Values
An dependent variable plotted on the ordinate.
Drug concentration
2 types of graph
Cartesian or Rectangular coordinates
Semilogarithmic graph
Allows placement of data at logarithmic intervals
Semilogarithmic graph
When using this, relationship is not confined to isolated points.
Curve fitting
Best describes the hypothesis and must satisfactorily fit experimental or observed data.
Emperical Equation
Not always linearly related
Physiologic Variables
Very useful for accurately predicting values for there are no experimental observations.
Straight line
2 mathematical function that is related to each other.
Exponential and Logarithmic function
Determines degree of ionization of drug
PH of Biological drug
Process is always constant and independent
First order kinetic
assumes a linear or straight-line function between
data points
Trapezoidal rule
Assumes a linear or straight line function
Trapezoidal rule
Independent in drug concentration
Zero order kinetics
Half life is not constant
Zero order kinetics
Dependent on drug concentration
First order kinetics
Half life is always constant
First order kinetics
