Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Nursing Pharmacology > Module 16 - Part 2 > Flashcards

Module 16 - Part 2 Flashcards

You may prefer our related Brainscape-certified flashcards:
Nursing Pharmacology flashcards Nursing Mental Health flashcards Nursing Management of Care flashcards NCLEX-PN® flashcards NCLEX-RN® flashcards Nursing Fundamentals flashcards Nursing Pediatrics flashcards Nursing Safety & Infection flashcards Nursing Maternity flashcards Family Nurse Practitioner (FNP) flashcards
1
Q

Penicillin

  • Discovered by?
  • Mechanism of action?
  • Net result?
  • Antibiotic type?
  • Effective against which type of bacteria?
A

Sir Alexander Fleming
Inhibits Transpeptidases and activates autolysins
Causes breakdown of the cell wall, influx of water and lysis of the bacterium
Bactericidal
Effective against gram positives due to large cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the two PBPs?

A

PBPs = penicillin binding proteins
Transpeptidase
Autolysin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Enzymes that function to form cross-bridges between the peptidoglycan strands, therefore making the cell wall strong.

A

Transpeptidases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Bacterial enzymes that degrade the peptidoglycan cell wall

A

Autolysins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How may penicillin resistance come about?

A

Inability to reach its target (see efflux/uptake)
Inactivation of penicillin
Mutations in PBPs making them have low affinity for penicillins (e.g. MRSA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Predominant mechanism of resistance against penicillins.

A

Beta lactamases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the different classes of penicillins?

A

Narrow spectrum penicillins
Narrow spectrum penicillinase resistant penicillins
Broad spectrum penicillins
Extended spectrum penicillins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Narrow spectrum penicillins:

  • Effective against what?
  • Administration and reasoning behind it.
  • Effective in treating what infections?
  • Adverse effect profile
A

Effective against gram positives
Administered by IV or IM since some are destroyed by gastric acid
Effective in treating pneumonia and meningitis
Drug allergy is the primary side effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How are narrow spectrum penicillinase resistant penicillins resistant to penicillinase?

A

Have an altered side chain that makes them not susceptible to inactivation by beta-lactamase enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why aren’t narrow spectrum penicillinase resistant penicillins always used?

A

Less effective against non-penicillinase producing bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Narrow spectrum penicillinase resistant penicillins:
Effective against?
No effective against?
What bacteria are resistant?

A

Effective against penicillinase producing Staphylococci
Less effective vs. non penicillinase producing bacteria
Not effective in treating abscesses or penetrating into bone
MRSA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Broad spectrum penicillins:
Effective against?
Reason for being broad spectrum (i.e. mechanism)?
Inactivated by?

A

Effective against both gram +ve and -ve bacteria
Able to penetrate the outer membrane of gram negatives and are thus broader in spectrum
Readily inactivated by beta lactamases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Have the same mechanism of action as penicillins.

A

Cephalosphorins - inhibit transpeptidases and activate autolysins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Cephalosporins:

  • Antibiotic type (i.e. bacteri______)
  • As we move from 1st generation to the 4th generation, what occurs?
  • Most frequently reported side effect?
  • Why are these used when a person has an allergy to penicillin?
A

Bactericidal (same as penicillins)

1st –> 4th = drugs tend to increase in terms of their activity against gram negative bacteria, increase their ability to penetrate CSF and increase their resistance to beta-lactamase enzymes

Allergy

Cross reactivity of people with penicillin allergy is very rare, thus cephalosporins can be used in penicillin allergic persons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

When is vancomycin used?

A

Potentially toxic drug - used only to treat resinous infections such as those caused by MRSA, including osteomyelitis, meningitis, pneumonia and septicemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the mechanism of action of vancomycin?

A

Binds to precursors of cell wall synthesis to block transglycosylation in cross-bridge synthesis

17
Q

What are the side effects of vancomycin?

A

Ototoxicity

Rapid infusion - red person syndrome (extreme flusing, rash, itching, HTN] [infuse slowly to avoid)

18
Q

Describe the mechanism of action of Tetracyclines.

A

Bind to the 30S ribosomal subunit and prevent amino acid addition to the peptide chain

19
Q

Tetracyclines:

  • Antibiotic type?
  • Spectrum?
  • Effective in treatment of?
  • Adverse effects?
A

Broad spectrum, bacteriostatic (only block translation)

Effective in treating typhus fever, chlamydia, cholera
Adverse effects:
- GI irritation
- photosensitivity (mus always wear sunblock)
- susceptible to superinfection (since broad spectrum)

20
Q

Mechanism of action of macrolide antibiotics?

A

Block the 50S ribosomal subunit and block the addition of amino acids to the peptide chain

21
Q

Macrolide:

  • Antibiotic type
  • Adverse effects
A

Broad spectrum, bacteriostatic
Adverse effects:
- GI upset, QT interval prolongation

22
Q

Mechanism of action of oxazolidinones?

A

Bind to a specific region of the 50S ribosomal subunit to inhibit protein synthesis

23
Q

Oxazolidinones

  • antibiotic type
  • effective in treating what?
A 
Narrow spectrum (effective against gram positives), bacteriostatic
Effective in treating MRSA and VRE - reserved for this use
24
Q

Mechanism of action of aminoglycosides?

A

Bind to the 30S ribosomal subunit to prevent protein synthesis
Rapidly lethal to bacteria

25
Q

Aminoglycosides:

  • Antibiotic type?
  • adverse effects?
A

bactericidal, narrow spectrum (gram negative)

Irreversible ototoxicity, reversible nephrotoxicity

26
Q

Mechanism of action of sulfonamides and trimethoprim?

A

These antibiotics (although acting at different stages), block the synthesis of folic acid

27
Q

Often, these drugs are given in combination and result in bactericidal action.

A

Trimethoprim, sulfonamides

28
Q

If humans also use folic acid, how come sulfonamides and trimethoprim do not affect us?

A

We obtain folic acid from our diet

29
Q

What is the common use of sulfonamides and trimethoprim?

A

Treatment of UTIs

30
Q

Adverse effects of sulfonamides and trimethoprim?

A 
Hypersensitivity reactions (fever and photosensitivity)
Small risk of severe hypersensitivity called Steven-Johnson syndrome
31
Q

Mechanism of action of Fluoroquinolones?

A

Inhibit DNA gyrase and topoisomerase IV - block DNA replication

32
Q

Fluoroquinolones:

  • Antibiotic type?
  • Effective in treating?
  • Adverse effects?
A

Bactericidal, broad spectrum

  • Treatment of UTIs, osteomyelitis, soft tissue infections
  • AEs: GI symptoms (nausea, vomiting, diarrhea)
33
Q

Primary treatment for TB.

A

Isoniazid (only effective in treating TB)

34
Q

Mechanism of action of isoniazid?

A

Inhibit the synthesis of mycolic acid.

35
Q

Adverse effects of isoniazid?

A

peripheral neuropathy and hepatotoxicity

Nursing Pharmacology (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions