Module 12 Flashcards
Buffers definition:
solutions that contain a weak acid and its conjugated base or a weak base and its conjugated acid.
Buffer capacity?
each buffer has a limit to the amount of acid/base that can be added before the buffer loses its ability to resist change.
When do buffers resist change in pH?
When strong acids or bases are added in LIMITED quantity.
3 main buffers systems?
bicarbonate
phosphate
protein buffer
How does the respiratory system impact the carbonic acid buffer system?
blood CO2 levels
What factor of a acid/base drug compound can dictate the movement across a cell membrane?
the charge of the drug can dictate movement of acid/base drugs
What controls the charge of drug? (% ionization)
Both the pH of the solution and pKa of the drug
Why are local anesthetics weak bases?
pKa of these drugs are closer to the physiological pH that are more lipid-soluble unionized form, to allow better crossing of the axonal membrane to initiate onset.
What is directly related to the drug absorption via passive diffusion?
the amount of ionized: unionized drug
Acidic drugs are ___ able to be _____ in the stomach than basic drugs.
better; absorbed.
Basic drugs will be in the ____ form in the stomach.
protonated
