Module 1: Structure and Function of Cells and Tissues Flashcards
Describe the major differences between prokaryotes and eukaryotes
Prokaryotes:
- doesnt have a nucleus
- single cell
- DNA in cytoplasm
Eukaryotes:
- single or multi cell
- has nucleus
- DNA in nucleus
- membrane bound organelle
Name the 5 phases of mitosis
Early Prophase Late Prophase Metaphase Anaphase Telophase
Describe the major functional differences among the four tissue types
- Nervous Tissue: internal communication (brain, spinal cord, nerves)
- Muscle Tissue: contracts to cause movement (muscles attached to bones - skeletal) (muscles of heart (cardiac) (muscles of walls of hollow organs (smooth)
- Epithelial Tissue: forms boundaries between different environments, protects, secretes, absorbs, filters (skin surface - epidermis, linig of GI tract organs)
- Connective tissue: supports, protects, binds other tissues together (bones, tendons, fat and other soft padding tissue)
Describe the structure and function of epithelia
Structure: covers all the internal + external surfaces. Avascular + sits on basement membrane
Function: Cells determine function, shape and number and organisation. Barrier for body, protection, sensory, excreotry
What are the 5 types of epithelia and their function
- Exchange - simple squamous, allow movement of substance through + between the cells (blood vessels - capillaries)
- Protective - stratified squamous tightly connected by desmosomes, constantly replaced (skin)
- Ciliated - columnar/ cubodial. Create fluid currents, to move substances (airways of lungs, nose)
- Secretory epithelia - columnar. Protein secreting cells that make and release product (exocrine and endocrine glands)
- Transporting epithelia - simple columnar/ cubodial - selectively move substances between the lumen and extracellular fluid (cells lining GI tract )
Describe Early Prophase
Chromatin condenses to form chromosomes formation of mitotic spindle that holds the paired chromosomes
Describe Late Prophase
nuclear membrane breaks down, Spindle interacts with chromosomes
Describe Metaphase
Controsomes at the opposite ends of the cell. Chromosomes cluster at teh center with centromeres aliened at equator called metaphase plate
Describe Anaphase
Chromosomes split. A complete set of chromosomes is pulled towards each end
Describe Telophase
Formation of nuclear envelope. Breakdown of spindle, division of cytoplasm - cytokinesis 2 new daughter cells are formed
What is transcription and what factors does it need?
the process where DNA’s information is encoded in mRNA
- loosens histones at the gene transcription site
- binds to teh promoter of DNA, promoter contains teh strat point of the gene to be transcribed
- mediates the binding of RNA polymerase to the promoter
What are the 3 phases of transcription?
- Initiation: with help of transcription factors, RNA polumerase binds to promoter, pries apart the 2 DNA strands and initates mRNA synthesis at the start point on the template
- Elongation: the RNA polymerase moves along the template strand, elongating the mRNA transcript one base at a time, unwinds the DNA double helix before it and rewinds the double helix behind it
- Termination: mRNA synthesis ends when the termination signal is reached. RNA polymerase and the completed mRNA transcript are released
What is translation
Process where information on mRNA is decoded for building proteins.
The mRNA attaches to small ribosomal subunit which moves along the mRNA to find the start condon.
Condon is three based sequence on mRNA that completes 3-based sequence on DNA.
Initiator tRNA binds to the start codon, after whichteh smal ribosomal unit attaches with the large ribosomal unit, forming a functional ribosome.
Anticodon binds to a complementary codon and attaches amino acid to the forming polypeptide chain.
New amino acids are added by tRNA as the ribosome moves alogn the mRNA
What does the basement membrane do?
Connects epithelial cells to connective tissue. Supports + protects epithelial tissue. Prevents malignany cells from entering
What are the 5 types of epithelia and their function
- Exchange - simple squamous, allow movement of substance through + between the cells (blood vessels - capillaries)
- Protective - stratified squamous tightly connected by desmosomes, constantly replaced (skin)
- Ciliated - columnar/ cubodial. Create fluid currents, to move substances (airways of lungs, nose)
- Secretory epithelia - columnar. Protein secreting cells that make and release product (exocrine and endocrine glands)
- Transporting epithelia - simple columnar/ cubodial - selectively move substances between the lumen and extracellular fluid (cells lining GI tract )