Module 1: Section 5

Question 1

adverse effects

Answer 1

extension of theraputic effect (overdose), unrelated to main drug action (ex.naseua), alergic reaction,withdrawl and addiction, teratogenesis (fetus) , adverse biotransformation reaction (when drug is converted to a chemically reactive metabolite that cna bind to tissue components and cause tissue or organ damage)

Question 2

why is it difficult to predict adverse reactions

Answer 2

rarity of occurence, lenght of usage (dosent happen till later), may not e detectible in animals, time period specififty (ex, abnormalities in fetus)

Question 3

assesing frug toxcicty

Answer 3

theraputic index (td50/ed50)

Question 4

TD50

Answer 4

toxic dose in 50 percent of population

Question 5

ED50

Answer 5

dose of drug that is effective in 50 percent of population

Question 6

higher the therputic index

Answer 6

safer it is

Question 7

drug food interaction

Answer 7

tyramine, grapefruit