Module 1. Normal blood components, production and erythrocytes.

Question 1

Interleukin-1

Answer 1

Producer cells: monocytes and macrophages

Hormone actin & effect: activate and stimulate cytokine production by T-lymphocytes and bone marrow stromal cells.

Question 2

Interleukin-3

Answer 2

from: T-lymphocytes
action & effect: induce differentiation and mitosis of the CFU-S into either the CFU-GEMM (myeloid stem cell) or the CFU-L (lymphoid stem cell)

Question 3

Interleukin-5

Answer 3

From: T-lymphocytes

A & E: induces eosinophil growth and function.

Question 4

Granulocyte/Monocyte stimulating factor

Answer 4

From: Bone marrow stromal cells (eg. fibroblast, endothelial cells)
A & E: induces differentiation and mitosis of the CFU-GEMM into several series committed stem cells: CFU-Eo, CFU-GM, FU-baso, BFU-E, and BFU-meg. It also stimulates the phagocytic and cytotoxic functions of the neutrophils and macrophages.

Question 5

Erythropoietin

Answer 5

From: Kidney cells
A & E: induces maturation and mitosis in BFU-E, CFU-E, pronormoblast and developing NRBC; raised concentration of EPO over long periods of time also induces increased production of other myeloid cells

Question 6

Thrombopoietin

Answer 6

From: liver cells (also macrophages and endothelial cells)

A & E: induces maturation and mitosis in the CFU-Meg and developing magakaryocytes.