Module 1-chemo drugs Flashcards
0
Q
Antimetabolites
A
- cell cycle specific
- interfere with synthesis of nucleic acids
- methotrexate, 5-FU
- bone marrow suppression
- gi-toxicity
- intrathecally
1
Q
Alkylating Agents
A
Bind w/ nucleus acids
Nitrogen mustard, cyclophosphamide, chlorambucil
-bone marrow suppression, amenorrhea, azoospermia, carcinogenesis
2
Q
Antitumor antibiotics
A
- acts in DNA to disrupt DNA and RNA transcription
- doxorubicin, bleomycin, mitomycin c, antinomycin d
- skin ulceration, bone marrow suppression
- ca toxicity
- increase effects of rad therapy
3
Q
Hormonal agents
A
- eliminate and disrupt normal hormones
- tamoxifen, flutamide, megestrol acetate
- hot flashes, depression, loss of libido, increase endometrial cancer
4
Q
Nitrosoureas
A
- interfere wuth DNA synthesis
- carmustine, limustine, streptozocin
- delayed myelosupression
- gi and nephro toxicity
- lipid soluble
5
Q
Plant Alkyoids
A
- cell cycle specific
- stops cell replication in metaphase
- vinicristine, vinblastine, etoposide
- ulceration oof skin, myelosupression
- neuro toxicity
- from periwinkle plant
6
Q
Miscellaneous(chemo drugs)
A
- disrupt mitosis
- platinum compounds
- myelosupression
- nephro toxicity
