Module 1 - anatomy of the brain Flashcards
the central system is the ______ and _____ centre
integrating and commanding
cerebrum contains 83% of brain volume and is divided into:
cerebral hemisphere and diencephalon.
the _______ contains 50% of neurons.
cerebellum.
neurons are highly specialised, excitable cells, provide rapid communication and have high_______ rate
metabolic
glial cells provided structural support, insulation and….
regional metabolism.
grey matter (neuron cell bodies) …
nucleus (CNS) and ganglion (PNS).
white matter (myelinated axons)….
tract (CNS) and nerve (PNS)
caudal
toward the tail
rostral
toward the nose
spinal cord extends from the____ to the_____
foramen magnum to first or second lumbar vertebra
enlargements of spinal cord
cervical and lumbar where nerves for upper and lower limb arises.
conus medullaris
end of spinal cord - tapering conical structure below the lumbar enlargement
filum terminale
anchors spinal cord to coccyx.
cauda equina
roots of nerves that arise from the lumbar, sacral and coccygeal regions of spinal cord and travel down the vertebral column.
posterior (dorsal) horns
incoming terminals from peripheral sensory neurons + inter-neurons
anterior (ventral) horns
motor neurons that go to the periphery + inter-neurons
dorsal roots (afferent fibres)
connects with dorsal root ganglion - sensory axons to the cord from spinal nerve.
ventral roots (efferent fibres)
motor axons to muscle/organs through mixed spinal nerves.
enlarged grey matter in____and _____ regions as more neurons muscles of lower and upper limbs.
cervical; lumbar
white matter increases in dorsal____from lumbar to______ regions - reflects increasing addition of sensory fibres from addition of sensory fibres from caudal to rostral truck regions.
column: cervical.
paralysis
temporary or permanent loss of motor control.
paraesthesia
sensory loss
the brain contains__ventricles
4
cerebrospinal fluid (CSF) is produced by______ _____. it fills cerebral ventricles and spinal cord as well as the ______ space
choroid plexus: subarachnoid space.
CSF has a constant turn over rate of
500mL/day produced and drained.
CSF is drained into venous sinus through the…
arachnoid granulations.
the functions of CSF are…
buoyancy, protection, chemical stability.
location of puncture for CSF sampling is…
lumbar.
CSF flow pathway..
lateral ventricles to the third ventricle through the intraventricular foramen. the third and fourth ventricle are connected to each other by the cerebral aqueduct. CSF then flows in the subarachnoid space through the lateral and median apertures.
cerebral aqueduct
connects the third and fourth ventricles.
interventricular foramen
connects lateral ventricles. to third ventricle.
lateral aperture
holes in 4th ventricle that allows CSF to pass through. also called foramina of lushke.
components. of the lateral ventricles
anterior horn, body, posterior horn, and inferior horn
choroid plexus produces CSF in…
body and inferior horn of the lateral ventricles.
third ventricle is located….
between lateral ventricle and cerebral aqueduct, choroid plexus in the roof.
fourth ventricle is located….
between cerebellum and pons/medulla
the roof/floor the fourth ventricle is formed by….
superior medullary velum and the inferior medullary velum (choroid plexus). The floor is formed by the brainstem.
the fourth ventricle has three openings..
2 lateral apertures and 1 median aperture.
hydrocephalus
accumulation of fluid in the spaces of the brain - due to increase production of CSF, disturbance in absorbance into venous sinuses.
Gyri
ridges.
sulci
shallow grooves.
fissure
an opening; a groove; a split.
what sulcus separates the frontal and parietal lobe
central sulcus.
what sulcus separates the temporal, parietal and frontal lobes
lateral sulcus
what fissure separates the cerebrum and cerebellum…
transverse fissure.
what sulcus separates the parietal and occipital lobe?
parieto-occipital
insula cortex
lies medial to lateral sulcus.
function of meninges
cover and protect CNS. protect blood vessels and enclose venous sinuses. contain CSF and form partitions in skull.
Three layers of meninges
dura, arachnoid, pia
dura mater
tough mother, outer layer, protecting the brain and spinal cord.
two layers of dura mater function..
periosteal layer and meningeal layer - separate and form dural venous sinuses.
dura mater extends inwards to form..
flat partitions to subdivide the cranial cavity and limit excessive movement of the brain within the cranium
dura mater forms partitions between…
two cerebral hemispheres (falx. cerebri), cerebellum and. cerebrum (tentorium cerebelli), two cerebellar hemispheres (falx cerebelli)
falx cerebri..
lies in medial sagittal plane, partially separates cerebral hemispheres.
falx cerebri is attached to…
bony projection anteriorly (crista galli) and to upper surface of tentorium cerebelli posteriorly.
tentorium cerebelli
lies in the horizontal plane, separates cerebrum from cerebellum.
falx cerebelli
smaller dural fold runs along the vermis of the cerebellum and separates two cerebellar hemispheres.
subdural space…
space between dura mater and arachnoid mater - very narrow, contains film of fluid, may be enlarged by bleeding.
arachnoid mater..
delicate transparent membrane - connected to the pia mater by fine strands of connective tissue (arachnoid trabecula)
subarachnoid space..
a space in the meninges beneath the arachnoid membrane and above the pia mater that contains the CSF - contains blood vessels.
cisterna magna
large area of CSF collection between the cerebellum and the medulla.
superior cistern..
also called the superior cerebellar cistern; an enlarged region of subarachnoid space above the cerebellum below the tentorium cerebelli.
interpeduncular cistern…
lies between the peduncles. contains bifurcation of basilar artery
pontine cistern
lies over the pons.
arachnoid villi (granulations)
help recycle CSF to blood; look like little warts; allow CSF to general circulation and drain via venous sinuses.
superior sagittal sinus…
a venous sinus located in the midline just dorsal to the corpus callosum, between the two cerebral hemispheres.
Flow of CSF
lateral ventricle -> 3rd -> 4th -> arachnoid space -> out arachnoid villi into blood stream.
pia mater..
delicate membrane, follows contours of brain, including sulci.
pia mater characteristics…
enmeshes blood vessels, sends prolongations into brain tissue along with blood vessels (perivascular space), helps form the roof of ventricles, closely associated with choroid plexus and ependyma
perivascular space…
space filled by blood vessels that penetrate the pia mater and enter the neural tissue where nutrient exchange occurs.
ependyma…
membrane lining the central canal of the spinal cord and the ventricles of the brain.
spinal meninges….
dura mater, arachnoid mater, pia mater - NO PERIOSTEAL layer.
spinal meninges: subarachnoid space…
between arachnoid and pia mater meninges, contains CSF - because there is not periosteal layer, there is an epidural space which contains fat tissue and is largest at L2 where spinal cord ends.
epidural anaesthesia…
regional anaesthesia produced by injecting mediation into the epidural space of the lumbar or sacral region of the spine.
lumbar cistern…
subarachnoid space inferior to medullary cone that contains cauda equina and CSF.
cistern…
reservoir or water tank.
spinal meninges; pia mater specialisation..
denticulate ligament - supports the spinal cord within dural sheath to secure spinal cord in place
filum terminale - fibre running from conus medullaris to tail bone, anchoring ends of spinal cord for extra support of spinal cord.
filum terminale
fibrous extension of the pia mater; anchors the spinal cord to the coccyx
meningitis..
inflammation of the pia-arachnoid mater.
internal carotid artery..
artery that supplies blood to the brain, eyes, eyelids, forehead, nose, and internal ear.
basilar artery…
an artery, formed by the fusion of the vertebral arteries, that supplied blood to the brainstem and to the posterior cerebral arteries.
vertebral artery…
one of the important blood vessels that enter the brain from the back of the skull
the basilar artery divides into two…
posterior cerebral arteries.
the internal carotid artery branches into…
anterior and middle cerebral arteries.
circle of willis (cerebral arterial circle)…
R/L posterior cerebral arteries R/L posterior communicating arteries R/L internal carotid arteries R/L anterior cerebral arteries anterior communicating artery
circle of willis function..
- equalises blood pressure in the brain
- provided alternative channels if one vessel becomes blocked.
posterior cerebral arteries.
two large arteries , arising from the basilar artery, that provide blood to posterior aspects of the cerebral hemispheres, cerebellum, and brainstem, 3rd and lateral ventricles.
anterior cerebral arteries.
two large arteries, arising from the carotids, that provide blood to the anterior poles and medial surfaces of the cerebral hemispheres.
middle cerebral arteries
two large arteries, arising from the internal carotid arteries, that provide blood to most of the lateral surfaced of the cerebral hemispheres
Blood brain barrier
formed by tight junction between the endothelial cells lining the brain capillaries to create a selective barrier for nutrients which serves as a protective mechanism to maintain a stable environment for the brain.
stroke results in……
reduction of blood supply to the brain - occlusion of a cerebral artery.
ischemic stroke
a type of stroke that occurs when the flow of blood to the brain is blocked.
hemorrhagic stroke
cerebral blood vessel rupture.
stroke-related dysfunction: anterior cerebral artery
contralateral hemiplegia (one artery) or bilateral paralysis (two arteries) and impaired sensation - greatest in lower limb
stroke-related dysfunction: middle cerebral artery
severe contralateral hemiplegia and impaired sensation - greatest in upper limb and face.
SEVERE aphasia if the dominant hemisphere is affected.
stroke-related dysfunction: posterior cerebral artery
contralateral homonymous hemianopsia (visual loss in half the visual field in both eyes)
blood drainage of the brain
fine veins (brain) -> pial venous plexuses -> cerebral veins -> dural venous sinus (emissary veins e.g., scalp and face) -> internal jugular vein -> heart.
emissary veins
connect dural venous sinuses with veins outside the skull - a potential source of infection into cranial cavity
rupture = subdural hemotoma.
dural venous sinuses
large veins in the dura mater that drain the cranium - collect venous blood from the brain and direct it into the internal jugular veins of the neck.
subdural hemotoma
collection of blood under the dura mater.
venous sinuses
blood-filled space between two layers of dura mater. they receive venous blood from scalp and also receive CSF
superior sagittal sinus
lies along the superior border of the falx cerebri - joins the transverse sinus (right). arachnoid vili drain the CSF into the superior sagittal sinus.
inferior sagittal sinus
runs within the inferior margin of the falx cerebri and joins the straight sinus.
straight sinus
- within tentorium cerebelli
- joins left transverse sinus.
transverse sinus
LEFT continuous with straight sinus
RIGHT continuous with superior sagittal sinus.
sigmoid sinus
- forward continuation of transverse sinus
- opens into internal jugular vein.
cavernous sinus
lateral to the pituitary gland, linked with venous channels
- drains into the superior sagittal sinus: transverse sinus
- drains into the inferior sinuses: internal jugular vein.
posterior spinal arteries
supply posterior (dorsal) horns and posterior (dorsal) columns.
anterior spinal arteries
supply anterior (ventral) and lateral columns, gray matter (except for dorsal horn)
radicular arteries
supply the spinal nerves.