Module 1

Question 1

What is the Onset describing?

Answer 1

When plasma concentrations reach the therapeutic window

Question 2

What does duration refer to?

Answer 2

Length of time the plasma concentrations remain within the therapeutic window

Question 3

What does the intensity refer to?

Answer 3

Height of the plasma concentrations within the therapeutic window or toxic range

Question 4

What is Tmax refer to?

Answer 4

This refers to how long it takes for the drug to reach Cmax. These terms are directly correlated

Question 5

What is T1/2?

Answer 5

This describes half life

Question 6

What is the goal of dosing for therapeutic purposes?

Answer 6

Produce drug exposures that result in clinically relevant drug response

Question 7

What does AUC refer to?

Answer 7

Area under the curve describes the relationship between plasma concentration versus time curve

Question 8

What does Cpss describe?

Answer 8

Average steady state plasma concentration

Question 9

What is Cmax?

Answer 9

Maximum plasma concentration

Question 10

What are the primary PK parameters? (4)

Answer 10

Absorption rate Ka
Bioavailability F
Volume of Distribution Vd
Systemic Clearance Cls

Question 11

What are the secondary PK parameters? (3)

Answer 11

Half Life T1/2
Elimination rate constant (k)
Fraction Excreted (Fe)

Question 12

What are the derived PK parameters? (5)

Answer 12

Area under curve (AUC)
Steady state concentration (CSS)
Steady state concentration average (CSS ave)
Time to max concentration (Tmax)
Concentration Max (CMax)

Question 13

What is a linear PK relationship?

Answer 13

Predictable in nature:

Proportional increase of area under the curve or average plasma concentration,

with increases in dose

Question 14

What is a Non-linear PK

Answer 14

Non predictable relationship between dose and CP