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Hema 2 Lec > module 1 > Flashcards

module 1 Flashcards

1
Q 
3 mL of the blood is taken, and 1 mL
of the blood is in each test tubes. Start
two stopwatches as you see the blood
in the syringe. Keep the blood in the
water bath and check for clotting by
tilting each tube at intervals of 30 to
60 seconds. Tilt the tube to greater
than 90 degrees
A

Lee- White method

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2
Q

NV of Lee- White method

A

blood clots firmly within 4-8

minutes

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3
Q

This test is used to monitor heparin
therapy which prolongs the clotting
time.

A

Lee- White method

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4
Q 
The procedure is carried out at 37 deg
Celsius and the tube is tilted after the
first minute and thereafter 5-10
seconds intervals until the clot is
formed.
A

Activated coagulation time

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5
Q

NV - Activated coagulation time

A

coagulation time is complete in

less than 101 seconds

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6
Q

Reagents used in Prothrombin time

A

Thromboplastin and ionized calcium

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7
Q 
when the reagents are added
to citrated plasma, these substitute for
tissue factor activates factor X in the
presence of factor VII involving
platelets or procoagulants in the
intrinsic pathway.
A

Prothrombin time

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8
Q

NV - Prothrombin time

A

10-12 sec

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9
Q

Prolongation of PT when PTT is

normal, occurs only in

A

factor VII deficiency

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10
Q

Prolonged PT and and PTT occurs in

A

oral anticoagulation therapy, liver disease, Vit K deficiency and def of
common pathway

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11
Q

compares the local thromboplastic reagent against

international reagent

A

International normalized ratio (INR)

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12
Q

A normal INR is

A

1.0.

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13
Q

A normal INR is 1.0. Each increase

of 0.1 means

A

the blood is slightly

thinner (it takes longer to clot).

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14
Q

INR is related to the

A

prothrombin time (PT).

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15
Q

If there is serious liver disease and

cirrhosis, the liver may

A

the liver may not produce
the proper amount of proteins and
then the blood is not able to clot as it
should.

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16
Q

The test is performed in a citrated

blood.

A

Activated partial thromboplastin time

17
Q

The plasma is recalcified.

A

Activated partial thromboplastin time

18
Q

enhances the speed of contact

activation

A

Kaolin

19
Q

provides a surface on
which coagulation enzyme substrate
can occur

A

Phospholipid

20
Q

NV - Activated partial thromboplastin time

A

28-40 sec

21
Q

assess the intrinsic

coagulation pathway

A

Activated partial thromboplastin time

22
Q

APTT assess the intrinsic

coagulation pathway except

A

factor VII and platelets.

23
Q

Performed exactly the same as APTT
except that an activator is not included
in the thromboplastin reagent.

A

Partial thromboplastin time

24
Q

NV - Partial thromboplastin time

A

40- 100 sec

25
Q

is a thromboplastin like

substance that activates factor X.

A

Stypven

26
Q

When this reagent is added together
with platelets and CaCl2, the
coagulation process has begun at the
point of factor X activation.

A

Stypven

27
Q

Stypven time is used to detect

A

It is used to detect deficiencies in
prothrombin, fibrinogen, factor X and
factor V.

28
Q

Stypven time also called as

A

Russell’s viper venom time

29
Q

it is an enzyme that is found
in the venom of the Bothrops atrox
snake

A

Reptilase

30
Q

It is capable of converting
fibrinogen to fibrin and is not affected
by heparin.

A

Reptilase time

31
Q

A measured amount of thrombin is
added to plasma. The legth of time for
a fibrin clot to form is recorded as
thrombin time.

A

Thrombin time

32
Q

It measure the availability of

functional fibrinogen .

A

Thrombin time

33
Q

Prolonged thrombin time is found if

fibrinogen level is

A

low (below 75- 100 mg/dl)

34
Q

Patients with fletcher factor

deficiency will have a prolonged ———

A

APTT.

35
Q 
If the plasma + APTT reagent
mixture is incubated for 10 minutes,
the prolonged APTT will be
shortened to normal or almost
normal if the deficiency is due to
A

fletcher factor

36
Q

If the plasma + APTT reagent
mixture is incubated for 10 minutes,
the prolonged APTT will be

A

shortened to normal or almost

normal

Hema 2 Lec (1 decks)

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