Module 1

Question 1

Respiratory burst is the generation of _____

Answer 1

superoxide anion

Question 2

NADPH oxidase are found in all granules except:

Answer 2

primary (not found in primary)

Question 3

Fenton reaction is the generation of ____ free radical by using superoxide dismutase (SOD) and Iron

Answer 3

hydroxyl

Question 4

Generation of “Cellular Bleach” produces a very toxic free radical called ____ by using myeloperoxidase (MPO) and Cl-

Answer 4

HOCl (hypochlorous acid)

Question 5

Free radical generation by Neutrophils can be accomplished in 3 ways :

Answer 5

Respiratory Burst
Fenton Reaction
Cellular Bleach

Question 6

What cell bridge the innate and adaptive immune response?

Neutrophils
Macrophage
Monocytes
Dendritic Cells

Answer 6

Macrophages

Question 7

(T or B) Lymphocytes are able to recognize antigen that are processed and presented by other cells.

Answer 7

T

Question 8

(T or B) Lymphocytes are capable of recognizing a Variety of both soluble and presented forms of microbial antigen that includes protein, polysaccharides, lipids, and nucleic acids.

Answer 8

B

Question 9

_____- is a molecule or fragment that is too small to be immunogenic, but can be made so by binding to a larger carrier (protein) to generate antibody

Answer 9

Hapten

Question 10

____ is a small structure within an antigen that directly interacts with the antibody and T/B cell receptors. Also called antigenic determinant.

Answer 10

Epitope

Question 11

_____ is a part of macro structure of microbes or transformed self cells that can be recognized by antibodies, T cells and B cells, therefore this would be immunogenic.

Answer 11

Antigen

Question 12

In cytosolic pathway, a viral protein is tagged with Ubiquitin then loaded onto TAP which transfers the fragment to MHC (I or II) in the ER to be presented on the surface of cell

Answer 12

MHC I

Question 13

Antigen Processing: _____ Pathway for processing Intracellular proteins. (viral proteins)

Answer 13

Cytosolic

Question 14

Antigen Processing: ______ Pathway for processing phagocytosed proteins

Answer 14

Endocytic

Question 15

The purpose of the _____ Pathway is to weed out infected, transformed, and foreign self cells by T cells.

Answer 15

Cytosolic

Question 16

The purpose of the ____ pathway is to prime T cells to work with B cells to produce antibodies.

Answer 16

Endocytic

Question 17

MHC 11 dimer binds with protein CD74 in the ER then enter the Golgi then enter the Phagolysosome where _____ a protease will swap CD74 with CLIP. The Complex then bind to HLA-DM which allow the swap between CLIP and bacterial peptide, the complex dissociates with HLA and antigen is presented.

Answer 17

Cathepsin A

Question 18

MHC (I or II) are expressed by all nucleated cells.

Answer 18

I

Question 19

HLA has 3 alpha domains and a B2M (molecule on chromosome 15). Those that are polymorphic are ____

Answer 19

a1 and a2 (not a3 and B2M)

Question 20

MHC (I or II) is a heterodimer (with alpha and beta chain on each having 2 domains), multiple alpha/beta chains pair with subtypes (DP, DQ, DR), and only expressed on APCs.

Answer 20

II

Question 21

Polymorphism of MHC-II ARE found in the ____ domains

Answer 21

a1 and b1

Question 22

In the _____ MHC-II, the B chains are more polymorphic than A chains,.

Answer 22

classical