modified block 12 Flashcards

1
Q

the coventional AH pathways is also called

A

corneoscleral

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2
Q

main structures in the conventional AH pathway

A

TM and SC

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3
Q

which AH pathway is IOP dependent

A

conventional path

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4
Q

the unconventional AH pathway is also called

A

uveoscleral

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5
Q

main structure in the unconventional path

A

ciliary muscle bundle

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6
Q

which AH pathway is IOP independent

A

unconventional path

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7
Q

what are 3 big factors that affect IOP

A
  • peak in morning
  • corneal thickness
  • steroids
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8
Q

if a cornea is thicker than normal, how will the IOP be affected

A

abnormally high reading

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9
Q

2 ways to obstruct outflow

A
  • occlusive angle

- injury to TM

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10
Q

what are possible causes of an occlusive angle (5)

A
  • severe diabetes
  • uveitis
  • hyphema
  • pseudoexfoliative glaucoma
  • pigment dispersion glaucoma
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11
Q

what are possible causes of injury to TM (2)

A
  • fuch’s heterochromic iritis

- glaucomatocyclitic crisis

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12
Q

an acute rise in EVP result in what

A

1:1 ratio of increase IOP

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13
Q

4 main aging changes to the anterior chamber

A
  • reduced depth
  • reduced uveoscleral outflow
  • extracellular matrix plaque in TM
  • increased outflow resistance in the TM and SC
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14
Q

what has a big effect on the anterior chamber depth

A

cortical cataract

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15
Q

whey is there a reduction in uveoscleral outflow with age

A

increase in the amount of connective tissue in ciliary muscle

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16
Q

5 components of vitreous

A
  • water
  • collagen
  • hyaluronic acid
  • vitreal cells
  • vitamin C
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17
Q

what makes up 99% of the vitreous

A

water

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18
Q

what 2 components give vitreous the gel like texture

A

collagen interacting with hyaluronic acid

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19
Q

4 major functions of the vitreous

A
  • support
  • diffuse barrier
  • metabolic buffer
  • transparency
20
Q

what can affect the “support” function of the vitreous

A

PVD

also macular edema

21
Q

what can affect the “ metabolic buffere” function of the vitreous

A
  • reduce neovascularization in retina
  • neovascular galucoma
  • NSC
22
Q

what can affect the “ transparency” function of the vitreous

A
  • synchisis scintillation

- asteroid hyalosis

23
Q

accumulation of choesterol within vitreous

A

synchisis scintillations

24
Q

accumulation of calcium within vitreous

A

asteroid hyalosis

25
Q

the “metabolic buffer” function of the vitreous: it is a reservoir for what

A
  • vitamin C
  • potassium
  • glucose/glycogen
26
Q

what happens to the vitreous with age

A

it becomes more liquified

27
Q

the breakdown of the vitreous gel and aggregation of collagen due to increase of liquid portion

A

vitreous syneresis

28
Q

what is the msot common cause of PVD

A

vitreous syneresis

29
Q

what is a floater

A

aggregation of collagen

30
Q

change of gel structure most likely occur in what part of the vitreous

A

center

31
Q

what are the 3 layers of TF (from cornea to air)

A

mucus layer
aqueous layer
lipid layer

32
Q

Composition of: mucus layer

A

Mucin

33
Q

Composition of: lipid layer

A

Meibomian oil

34
Q

Composition of: aqueous layer

A
  • water (mainly)
  • Na and Cl (osmolarity)
  • K and Ca (corneal epithelium health)
  • Protein
35
Q

Function of: mucus layer

A
  • provide medium for aqueous layer
  • cover epithelium
  • trap debris and bacteria
36
Q

Function of: aqueous layer

A
  • provide protection
  • buffering
  • regulate cornea epithelium proliferation
37
Q

Function of: lipid layer

A

Slow the evaporation of aqueous layer

38
Q

Source of: mucus layer

A
  • primary: goblet cells

- squamous cells of cornea and conj

39
Q

Source of: aqueous layer

A
  • main lacrimal gland

- accessory lacrimal gland

40
Q

Source of: lipid layer

A
  • primary: meibomian gland

- zeis and moll

41
Q

Tests for tear secretion (4)

A
  • schirmer 1
  • schirmer 2
  • phenol red thread test
  • meinscometry
42
Q

Tests for tear film stability (4)

A
  • TBUT
  • ocular protection index
  • videokeratography
  • tear turnover
43
Q

Tests for tear film osmolarity (3)

A
  • tear film osmolarity
  • tear Ferning
  • tear evaporation
44
Q

Tests for lipid layer evaluation (2)

A
  • interferometry

- meibometry

45
Q

Tests for ocular surface evaluation (3)

A
  • fluorescein
  • Rosa bengal
  • lissamine green
46
Q

Secreted by the corneal epithelium

- helps mucus layer stay stable on the corneal epi

A

Glycocalyx

47
Q

Aging changes of the lacrimal system (5)

A
  • dec in goblet cells
  • reduced tear reflex secretion
  • change in composition of meibomian secretion
  • increase of plugged meibomian
  • reduced lacrimal drainage