Modes of action antidepressants

Question 1

Venlafaxine

Answer 1

Serotonin and noradrenaline reuptake inhibitor (SNRI)

Question 2

Duloxetine

Answer 2

Serotonin and noradrenaline reuptake inhibitor (SNRI) Also a weak inhibitor of dopamine reuptake

Question 3

Reboxetine

Answer 3

Noradrenaline reuptake inhibitor (NRI)

Question 4

Bupropion

Answer 4

Noradrenaline and dopamine reuptake inhibitor

Question 5

Trazodone

Answer 5

Weak SRI and 5HT agonist

Question 6

St John’s wort

Answer 6

Weak MAOI and weak SNRI (also thought to be an SSRI)

Question 7

Mirtazapine

Answer 7

Noradrenaline and serotonin specific antidepressant (NaSSa). 5HT-1, 5HT-2, 5HT-3 and H1 antagonist, presynaptic alpha 2 antagonist (This stimulates the release of NA and 5HT)