Modern Chemotherapy Med Chem Flashcards
1
Q
What are PARP inhibitors?
A
Ribs
2
Q
What are Tyrosine Kinase inhibitors?
A
Nibs
3
Q
What does PARP stand for?
A
Poly(ADP) Ribose Polymerase.
4
Q
What are the target for PARP inhibitors?
A
BRCA1 & BRAC2
5
Q
How do PARP inhibitors work?
A
If PARP is inhibited, single strand breaks cannot be repaired.
Results in DNA with lots of single strand breaks.
These are either repaired by homologous recombination or lead to cell death.
6
Q
What are the target for tyrosine kinase inhibitors?
A
BRAF inhibitors.
7
Q
What is the mutation in the BRAF protein?
A
Single amino acid mutation at V600E.
8
Q
Name some BRAF inhibitors.
A
Sorafenib, Vemurafenib, Dabrafenib.
9
Q
How is resistance made to tyrosine kindase inhibitors?
A
Small mutations in target protein prevent the binding of the kinase inhibitor.
