Moderate Risk Genes

Question 1

Gene: ATM

Answer 1

Syndrome/Pathway: Ataxia-Telangiectasia

Cancer Spectrum/Risks: 25-30% breast, CRC, pancreas

Question 2

Gene: CHEK2

Answer 2

Syndrome/Pathway: DNA Repair

Cancer Spectrum/Risks: 28-38% breast, <50% prostate, thyroid, CRC, male breast, ovarian, uterine

Question 3

Gene: PALB2

Answer 3

Syndrome/Pathway: Fancomi Anemia

Cancer Spectrum/Risks: 25-50% breast, <10% pancreas, ovarian