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PHASE 2A DRUG LIST > MODE OF ACTION > Flashcards

MODE OF ACTION Flashcards

1
Q

ALENDRONATE

MoA

A

Inhibits osteoclast mediated bone resorption by inhibiting the enzyme FPP synthase

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2
Q

ATENOLOL

MoA

A

Binds to beta-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation

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3
Q

ATRACURIUM

MoA

A

Binds competitively with cholinergic receptor sites to antagonise acetylcholine action

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4
Q

BENDRO-FLUMETHIAZIDE

MoA

A

Inhibits Cl reabsorption at early distal tubule, results in increase of Na, Cl and water excretion

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5
Q

CEFUROXIME

MoA

A

Inhibition of bacterial cell wall synthesis -> death due to lysis

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6
Q

CELECOXIB

MoA

A

Inhibits Cox-2 cyclooxygenase -> inhibits prostaglandin synthesis

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7
Q

CHLORAMPENICOL

MoA

A

Bacteriostatic – inhibits protein synthesis by interfering with substrate binding

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8
Q

CICLOSPORIN

MoA

A

lymphocyte function

Binds to cytosolic protein, inhibiting calcineurin -> less inflammatory cytokine production

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9
Q

CIPROFLOXACIN

MoA

A

Inhibition of bacterial DNA gyrase enzyme -> prevents DNA replication so stops replication

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10
Q

CO-AMOXICLAV

MoA

A

Beta-lactamase inhibitor + inhibits penicillin binding proteins -> inhibits bacterial cell wall synthesis

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11
Q

DIAMORPHINE

MoA

A

Mu-opioid agonist

Acts on receptors in the CNS which produces an analgesic effect

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12
Q

DALTEPARIN

MoA

A

Inhibits the formation of factor Xa and thrombin

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13
Q

DOBUTAMINE

MoA

A

Directly stimulates Beta-1 receptors in the heart, increases myocardial contractility and stroke volume

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14
Q

DOXAZOSIN

MoA

A

Inhibits postsynaptic alpha 1 adrenoceptors on vascular smooth muscle – peripheral vasodilation

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15
Q

EPHEDRINE

MoA

A

Stimulation of adrenergic receptors

Increases noradrenaline action and release

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16
Q

ERYTHROMICIN

MoA

A

Inhibits bacterial protein synthesis

Bacteriostatic/cidal dependent on dose

17
Q

ETHINYLESTRADIOL

MoA

A

Interaction with oestrogen receptors in target cells

18
Q

FUROSEMIDE

MoA

A

Inhibits water reabsorption in the nephron (blocks Na-K-Cl cotransporter)

19
Q

IPRATROPIUM

MoA

A

Blocks muscarinic ACh receptors, promoting cGMP degradation – reduces bronchoconstriction

20
Q

LOPERAMIDE

MoA

A

Acts on mu-opioid receptors in PNS -> slows intestinal motility
Doesn’t cross the BBB so can’t affect CNS

21
Q

METFORMIN

MoA

A

Decreases hepatic glucose production and intestinal glucose absorption
Improves insulin sensitivity

22
Q

METHOTREXATE

MoA

A

Cancer – inhibition of DHFR, inhibiting folate synthesis.

Arthritis – inhibition of purine metabolism = accumulation of adenosine = suppression of T cells

23
Q

OXYBUTININ

MoA

A

Antagonist of M1, 2 & 3 muscarinic ACh receptors

Decreases muscle spasms of the bladder

24
Q

PARACETAMOL

MoA

A

COX enzyme inhibition in CNS indirectly

25
Q

RAMIPRIL

MoA

A

Inhibit ACE activity
Less Angiotensin II produced
Less Bradykinin breakdown
Relaxation of arterial smooth muscle

26
Q

RIFAMPICIN

MoA

A

Inhibits bacterial RNA polymerase enzyme – no RNA synthesis

27
Q

RIVAROXIBAN

MoA

A

Competitive irreversible inhibition of factor Xa.

Prevents thrombin formation

28
Q

SALMETEROL

MoA

A

Beta 2 stimulation causes relaxation of bronchial smooth muscle

29
Q

SILDENAFIL

MoA

A

Increases cGMP to cause smooth muscle relaxation - vasodilation

30
Q

SUXAMETHONIUM

MoA

A

Mimics ACh at NM junction, with slow hydrolysis – prolongs depolarisation = NM blockade

31
Q

TAMSULOSIN

MoA

A

Selective A1 antagonist

Causes relaxation in smooth muscle = less resistance to urinary flow=less pain in BPH

32
Q

TRAMADOL

MoA

A

Agonist of mu-opioid receptors
Serotonin & norepinephrine reuptake inhibitor
Enhances serotonin release

PHASE 2A DRUG LIST (5 decks)

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