MODA practical paper

Question 1

DR/Bmax =

Answer 1

DK/(DK+ 1)

Question 2

Scatchard plot

Answer 2

Bound/free vs bound. X intercept is Bmax and slope is -K.

Question 3

Dose ratio =

Answer 3

AK’ + one.

Question 4

Schild equation

Answer 4

log (DR - 1) = logA + logK

Question 5

Schild plot may be curvilinear if…

Answer 5

there are multiple types of receptor or there is an agonist depleting process present.

Question 6

Cheng Prusoff equation

Answer 6

K’ = (1 + [L]Kl)/IC50

Question 7

AUC =

Answer 7

Cp/Ke

Question 8

Fxdose = AUC….

Answer 8

AUC x Cl

Question 9

C(0) =…

Answer 9

FxDose/Vd

Question 10

Clearance = Vd x …

Answer 10

Vd x ke

Question 11

Clearance = F x dose/…

Answer 11

F x dose/AUC

Question 12

Cmax (ss)/Cmax(0) =

Answer 12

1/(1-f) where f= e to the -kT

Question 13

Cmin(ss) =…

Answer 13

Cmax(ss) x e to the -kT

Question 14

Maintenance dose =

Answer 14

loading dose x (1-f)

Question 15

C(avss) =

Answer 15

F x dose rate/ clearance

Question 16

C(t)=

Answer 16

C(0) x e (to the -kt)

Question 17

Before steady state C(t) =

Answer 17

Css(1-f) where f = e to the -kT

Question 18

What affects the first pass effect?

Answer 18

Hepatic enzymes, but also GI lumen enzymes, GI gut wall enzymes and bacterial enzymes. Route of administration.

Question 19

Hill plot

Answer 19

log (B/(Bmax-B)) vs log(D)

Question 20

EC50s and antagonists

Answer 20

A competitive antagonist increases EC50 but has no effect on max response.
A non-competitive antagonist increases EC50 and decreases max response.

Question 21

When finding AUC

Answer 21

plot lnCp vs time

Question 22

Avogadro’s constant

Answer 22

6.022 x 10to the 23

Question 23

clearance = rate of elimination/?

Answer 23

rate of elimination/plasma conc.

Question 24

Cmax - Cmin =

Answer 24

dose x availability/volume of distribution