MOD Ch3 Flashcards
Exudate
High protein, may have white or red cells
Transudate
Low protein, with few cells
Histamine, source
Mast cells, basophils, platelets
Prostaglandins, source
Mast cells, leukocytes
Leukotrienes, source
Mast cells, leukocytes
Cytokines (TNF, IL-1, IL-6), source
Macrophages, endothelial cells, mast cells
Chemokines, source
Leukocytes, activated macrophages
Platelet-activating factor, source
Leukocytes, mast cells
Complement, source
Plasma (liver)
Kinins, source
Plasma (liver)
Histamine, action
Vasodilation, permeability, endothelial activation
Prostaglandins, action
Vasodilation, pain, fever
Leukotrienes, action
Permeability, chemotaxis, leukocyte adhesion and activation
Cytokines, action
Endothelial activation, fever, metabolic abnormalities, hypotension
Chemokines, action
Chemotaxis, leukocyte activation
Platelet activating factor, action
Vasodilation, permeability, leukocyte adhesion, chemotaxis, degranulation, oxidative burst
Complement, action
Leukocyte chemotaxis and activation, MAC, vasodilation
Kinins, action
Permeability, smooth muscle contraction, vasodilation, pain
Neutrophils, action
Azurophil (primary) granules–> myeloperoxidase
NETs trap and kill microbes
Can cause toxic granulation in sepsis
Hereditary Angioedema
C1 inhibitor deficiency
Paroxysmal Nocturnal Hemoglobinuria
Acquired deficiency in GPI anchors that hold:
DAF (normally inhibits C3 convertase)
CD59 (normally inhibits MAC)
Activator for M1
IFN-gamma
Activator for M2
IL-13, IL-4
M1 releases:
IL-1, IL-12, IL-23, chemokines–> Inflammation
ROS, NO, lysosomal enzymes–> Microbicidal
M2 releases:
IL-10, TGF-beta–> Anti-inflammatory
Growth factors, TGF-beta–> Tissue repair, fibrosis
Th1 releases:
IFN-gamma, IL-2
Th17 releases:
IL-17a, IL-17f, IL-21, IL-22
Th2 releases:
IL-4, IL-13, IL-5
Acute inflammation cytokines
TNF, IL-1, IL-6, Chemokines, IL-17
Chronic inflammation cytokines
IL-12, IFN-gamma, IL-17
