MOD Ch3

Question 1

Exudate

Answer 1

High protein, may have white or red cells

Question 2

Transudate

Answer 2

Low protein, with few cells

Question 3

Histamine, source

Answer 3

Mast cells, basophils, platelets

Question 4

Prostaglandins, source

Answer 4

Mast cells, leukocytes

Question 5

Leukotrienes, source

Answer 5

Mast cells, leukocytes

Question 6

Cytokines (TNF, IL-1, IL-6), source

Answer 6

Macrophages, endothelial cells, mast cells

Question 7

Chemokines, source

Answer 7

Leukocytes, activated macrophages

Question 8

Platelet-activating factor, source

Answer 8

Leukocytes, mast cells

Question 9

Complement, source

Answer 9

Plasma (liver)

Question 10

Kinins, source

Answer 10

Plasma (liver)

Question 11

Histamine, action

Answer 11

Vasodilation, permeability, endothelial activation

Question 12

Prostaglandins, action

Answer 12

Vasodilation, pain, fever

Question 13

Leukotrienes, action

Answer 13

Permeability, chemotaxis, leukocyte adhesion and activation

Question 14

Cytokines, action

Answer 14

Endothelial activation, fever, metabolic abnormalities, hypotension

Question 15

Chemokines, action

Answer 15

Chemotaxis, leukocyte activation

Question 16

Platelet activating factor, action

Answer 16

Vasodilation, permeability, leukocyte adhesion, chemotaxis, degranulation, oxidative burst

Question 17

Complement, action

Answer 17

Leukocyte chemotaxis and activation, MAC, vasodilation

Question 18

Kinins, action

Answer 18

Permeability, smooth muscle contraction, vasodilation, pain

Question 19

Neutrophils, action

Answer 19

Azurophil (primary) granules–> myeloperoxidase
NETs trap and kill microbes
Can cause toxic granulation in sepsis

Question 20

Hereditary Angioedema

Answer 20

C1 inhibitor deficiency

Question 21

Paroxysmal Nocturnal Hemoglobinuria

Answer 21

Acquired deficiency in GPI anchors that hold:
DAF (normally inhibits C3 convertase)
CD59 (normally inhibits MAC)

Question 22

Activator for M1

Answer 22

IFN-gamma

Question 23

Activator for M2

Answer 23

IL-13, IL-4

Question 24

M1 releases:

Answer 24

IL-1, IL-12, IL-23, chemokines–> Inflammation

ROS, NO, lysosomal enzymes–> Microbicidal

Question 25

M2 releases:

Answer 25

IL-10, TGF-beta–> Anti-inflammatory

Growth factors, TGF-beta–> Tissue repair, fibrosis

Question 26

Th1 releases:

Answer 26

IFN-gamma, IL-2

Question 27

Th17 releases:

Answer 27

IL-17a, IL-17f, IL-21, IL-22

Question 28

Th2 releases:

Answer 28

IL-4, IL-13, IL-5

Question 29

Acute inflammation cytokines

Answer 29

TNF, IL-1, IL-6, Chemokines, IL-17

Question 30

Chronic inflammation cytokines

Answer 30

IL-12, IFN-gamma, IL-17