Mod 3

Question 1

Delirium Associated Morbidity

Answer 1

10x risk of death in hospital (as high as 50% in 1 yr) Lingering cog dysfunction 6-24 months 3-5x increased risk of nosocomial complications 50% require post acute care increased risk of death up to 2 yrs after DC 4x likely to develop dementia

Question 2

neuropathophusiology of delirium

Answer 2

cholinergic deficiency (acetylcholine is an important neurotransmitter for cog processes)

Question 3

Pharm Mgmt for delirium

Answer 3

to mediate and correct the disturbance in nuerotransmission

Question 4

Lab testing for delirium

Answer 4

CBC, electrolytes, renal function, UA, LFTs, serum drug levels, ABG, CXR, ECG, cultures

Question 5

precipitating factors for delirium

Answer 5

acute cardiac and pulmonary events ETOH fecal impaction indwelling devices fluid/electrolyte imbalances bed rest meds restraints severe anemia uncontrolled pain urinary retention infx

Question 6

lab values predictive of delirium

Answer 6

elevated Na+, K+, Cl, glucose elevated BUN to creatinine ratio leukocytosis, alkalosis, hypoxemia, hypoalbuminemia

Question 7

medications used for delirium

Answer 7

risperidone, quetiapine, ariprazole, olanzapine, ziprasidone

Question 8

Cognitive domains

Answer 8

Complex attention Executive functioning Learning and Memory Language Perceptual-Motor Social Cognition

Question 9

What is delirium?

Answer 9

Disturbance in attention and awareness within a short period of time

“Fluctuating consciousness and attention”