Mock Test A Flashcards

1
Q

Adrenaline dose in Anaphylactic shock <6 months old

A

100 - 150 micrograms
0.1 - 0.15 ml in 1,000

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2
Q

Adrenaline dose in Anaphylactic shock for adults and > 12 years old

A

500 micrograms IM every 5 mins
(0.5ml 1 in 1,000)

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3
Q

Flank discolouration in acute pancreatitis is called

A

Grey-Turner’s sign
Caused by blood vessel auto-digestion by pancreatic enzymes, resulting in retroperitoneal haemoorhage => low Hb

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4
Q

GRACE score (global Registry of Acute Coronary Events)

A

Predicted 6-month mortality:
1.5% or below - lowest
1.5 to 3.0% - Low
3.0 to 6.0% - Intermediate
6.0% to 9.0% - High
over 9.0% - Highest

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5
Q

Scars seen over metacarpophalangeal joints due to fingers scraping front teeth

A

Russell sign seen in Bulimia nervosa during episodes of induced vomiting

Remember: Bulimia nervosa has normal BMI

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6
Q

Kleine-Levin syndrome

A

Irregularly recurring hyPERsomnia
Associated with binge-eating, sexual behaviour disinhibition and mood disorders
Often seen in young males

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7
Q

Transmission of Hepatitis A

A

Faecal oral

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8
Q

Incubation period for Hepatitis A
(RNA picornavirus)

A

2-4 weeks
Benign, self limiting disease
WIth flu-like prodrome

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9
Q

Type of antibiotic class for Clarithromycin

A

Macrolides
Can cause long QT

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10
Q

Macrolides are inhibitor / inductor of cytochrome P450

A

Inhibits

CYP450 enzyme metabolises statins - which means statins concentration rises if we don’t hold statins whilst on macrolides, significantly increases the risk of rhabdomyolysis and myopathy

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11
Q

When should cervical smear be repeated as Test of Cure after CIN treatment

A

6 months

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12
Q

When should referral for colposcopy be made
If inadequate smear result

A

2 consecutive inadequate smears 3 months apart

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13
Q

If routine cervical smear is inadequate, what’s next step

A

Repeat next smear in 3 months time

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14
Q

M rule in primary biliary cholangitis

A

IgM
anti-Mitochondrial antibodies, M2 subtype
Middle aged females

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15
Q
  • pruritus
  • fatigue
  • raised ALP on routine LFT
  • hyperpigmentation
  • RUQ pain
  • xanthelasmas, xanthomata
  • cholestatic jaundice

Above are early symptoms of

A

Primary biliary cholangitis (previously biliary cirrhosis)

most probably auto-immune cause
9:1 females to males ratio

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16
Q

Primary Biliary Cholangitis usually associated with what conditions

A

Sjogren’s syndrome (80% of patients)
Rheumatoid arthritis
Systemic sclerosis
Thyroid disease

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17
Q

Pneumothorax can be classed as secondary when there is

A

Some underlying lung disease such as COPD

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18
Q

PTX patient can be considered for discharge if the rim of air is how big in cm

A

< 1cm in secondary pneumothorax (or aspirated and subsequently)
Or <2cm in primary pneumothorax

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19
Q

NAFLD (non-alcoholic fatty liver disease) has LFTs like:

A

Raised ALT > AST

(now most common cause of liver disease in the developed world)
usually seen in fat people
Hepatic manifestation of metabolic syndrome = insulin resistance is key leading to steatosis

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20
Q

Indapamide is what type of diuretic

A

Thiazide diuretic
- causes reduced clearance of lithium

21
Q

What prophylactic antibiotic should you give to families of meningococcal meningitis

A

Oral ciprofloxacin (single dose)
or oral rifampicin (BD for 2 days)

22
Q

Routine recall ages for cervical smear screening >50 years old

A

Every 5 years

23
Q

IM methylprednisolone is indicated for

A

NICE guidelines for acute flare of rheumatoid arthritis

corticosteroids (methylprednisolone) have primarily glucocorticoid effect and result in inhibition of pro-inflammatory cytokine production

24
Q

Treatment for flare of ulcerative colitis (mild -> systematically well)

A

Topical (rectal) mesalazine -> Oral aminosalicylate -> oral steroids

25
Examples of aromatase inhibitor used in oestrogen receptor positive breast cancer
Anastrozole, Letrozole Reduces peripheral oestrogen synthesis Be careful of osteoporosis! needs DEXA scan prior to starting
26
SERM (selective oestrogen receptor modulators) mechanism of action
Tamoxifen Acts as oestrogen receptor antagonist and partial agonist
27
Adverse effects of SERM (eg Tamoxifen)
Menstrual disturbances (vaginal bleeding, amenorrhoea) Hot flushes VTE Endometrial cancer
28
Poorly controlled hypertension already on ACE inhibitor we should add
Thiazide diuretic (indapamide) or CCB
29
Hypertension in age <55 or T2DM we should start with
ACE inhibitor or ARB
30
Hypertension in >55 years or Afro-Carribbean we should start with
CCB Becoz ACE inhibitors have reduced efficacy in black patients
31
Max dose of ramipril
10mg OD
32
Clozapine in schizophrenia
Should be added on if not responded to at least 2 antipsychotics Remember agranulocytosis & neutropaenia!
33
Anticoagulation in AF post-stroke: when should we start?
Should be started in 2 weeks post-stroke in the absence of haemorrhage Give antiplatelet therapy in the interim
34
Iron deficiency anaemia in patient aged >50 suspect which type of cancer?
Colorectal cancer
35
BTS guidelines for emergency oxygen therapy in COPD Co2 retainers says
Hypoxia kills. GIve 15L/min in non-rebreathe for those who are critically ill then wean later once stable.
36
Biopsy reults of breast tissue: local area of epithelial proliferation in large mammary ducts
Duct papilloma hyperplastic lesions rather than malignant or premalignant
37
Paget’s disease of breast is
intraductal carcinoma Reddening and thickening of nipple/areola
38
Meconium ileus common presents in when hours of life
24-48 hours of life abdominal distension and bilious vomiting (more common in cystic fibrosis)
39
Abdominal XR shows double bubble sign in neonates means
Duodenal atresia - bilious vomiting @ few hours after birth is a symptom - high incidence in downs syndrome
40
Mebendazole is first-line treatment for
Threadworms
41
Conductive hearing loss can be tested by Rinne or Weber’s ?
Rinne’s normal is - air conduction > bone conduction
42
Sensorineural hearing - Weber’s ringing loudest in one side means
The loudest side is the one working
43
Acute epiglottis is caused by what bacteria
Haemophilus influenza type B - stridor - drooling of saliva - high temperature - tripod position ‘Thumb sign” on xray
44
Uncomplicated perforated tympanic membrane, child systematically well, what do we do?
Leave it and will usually heal in 6-8 weeks Avoid getting water in ear during this time May prescribe antibiotics
45
Malignant otitis externa is extension of infection into the bony ear canal and soft tissues deep to the bony canal. Whom is this condition mostly seen in?
Elderly diabetics Will need treatment with IV Abx
46
How is haemophilia inherited?
X-linked recessive In females - they must either receive two copies of faulty X gene (X carrier from mum and X from dad who is also a haemophiliac) or is Turner’s syndrome
47
1-week history of flu like prodrome, headaches, lethargy and muscle aches then onset of diarrhoea including right lower abdominal pain and bloody diarrhoea is likely diagnosis of?
Campylobacter jejuni gastroenteritis
48
In patients with vitamin B12 and folate deficiency, which one must be treated first?
VItamin B12 must be replaced first To avoid subacute combined degeneration of spinal cord