MOAs for Test 4 Flashcards
(45 cards)
(Lecture 1) This class of drugs blocks the reuptake of norepinephrine and serotonin (precursors to SNRI) into the presynaptic neuron which increases [monoamine] in the synaptic cleft (debated); also blocks alpha adrenergic, histamine, and muscarinic receptors.
Tricyclic Antidepressants
(Lecture 1)
This drug class Inhibits serotonin reuptake, without affecting reuptake of norepinephrine or dopamine into the presynaptic neuron;
they DO NOT SIGNIFICANTLY EFFECT histamine, muscarinic, or other receptors
SSRIs
(Lecture 1)
These drugs/classes carry a risk of serotonin syndrome because they INHIBIT SEROTONIN REUPTAKE
- Cocaine
- Dextromethorphan (DM)
- Meperidine
- SSRIs
- TCAs
- Trazodone
- Venlafaxine
(Lecture 1) This drug/class carries a risk of serotonin syndrome because it is a DOPAMINE AGONIST
L- dopamine
(Lecture 1) This drug/class carries a risk of serotonin syndrome because it is a SEROTONIN PRECURSOR
L-tryptophan
(Lecture 1) These drug/class carries a risk of serotonin syndrome because it INHIBITS SEROTONIN METABOLISM
MAOIs
(Lecture 1)
These drugs/classes carry a risk of serotonin syndrome because they INCREASE SEROTONIN RELEASE
- Amphetimines
- Lithium
- MDMA (ecstacy)
(Lecture 1)
These drugs/classes carry a risk of serotonin syndrome because they are SEROTONIN RECEPTOR AGONISTS
- Triptans
- Buspirone
- Lysergic Acid Diethylamide
(Lecture 1)
This drug class inhibits the reuptake of 5HT and NE, increasing their levels (may be dose-related);
it displays LITTLE activity for alpha-adrenergic, cholinergic, or histamine receptors
SNRIs
(Lecture 1)
This drug inhibits dopamine AND Norepinephrine (at high doses) with minimal activity on serotonin
Bupropion (an NDRI)
(Lecture 1)
This drug modestly inhibits serotonin uptake (less than SSRIs); are antagonist for pre-synaptic 5HT(2A), H(1), and alpha(1) receptors
Trazodone
a serotonin receptor antagonist
(Lecture 1)
This drug inhibits 5HT(2A), H(1), and alpha(1) receptors AND ALPHA 2 receptors, but does not have reuptake inhibition effect.
Mirtazapine
a serotonin Receptor Antagonist
(Lecture 1)
This drug inhibits 5HT(2) family of receptors, alpha(1) receptors, and reuptake of serotonin and norepinephrine
Nefazodone
a serotonin receptor antagonist
(Lecture 1) This drug class blocks the enzyme responsible for the breakdown of NE, dopamine, and serotonin which increases the stores of these neurotransmitters in the neurons
MAOIs
Two forms: MAO-A, MAO-B
Foods that interact with these medications occur because they inhibit MAO in the GI tract that normally breaks down tyramine, resulting in increased levels of catecholamines.
(Lecture 1)
These drugs are non-selective MAOIs which are considered last line agents in antidepression
Phenelzine
Tranylcypromine
(Lecture 1)
This MAO-B INHIBITOR is used in the treatment of MDD (and Parkinson’s) and claims to exhibit longer time to relapse and less sexual dysfunction and weight gain
Selegiline Transdermal System
(Lecture 1)
The MOA of this drug is unknown, but may inhibit 2 signal transduction pathways; it is used in the tx of the manic phase for bi-polar patients and anti-manic effects can occur in 1-2 weeks; it appears to be neuroprotective.
Lithium
(Lecture 2) This drug class acts directly on postsynaptic dopamine receptors and do not require enzymatic conversion. Specifically, D2 receptor stimulation improves rigidity and bradykinesia in Parkinson's
Dopamine agonists
(Lecture 2)
This short-acting dopamine agonist stimulates post-synaptic D2-type receptors
Apomorphine
Will probably cause severe N/V… prophylax with trimethobenzamide
(Lecture 2)
This Aromatic L-amino Acid Decarboxylase (AAAD) inhibitor DOES NOT CROSS THE BBB; prevents peripheral conversion and metabolism of levopdopa to dopamine in the peripheral tissues, thereby allowing increased availability of levodopa to cross into the CNS
Carbidopa
(Lecture 2)
This precursor to dopamine HAS THE ABILITY TO CROSS THE BBB and replenish depleted dopamine in the brain; it is CONVERTED TO DOPAMINE IN THE PERIPHERY
Levodopa
(Lecture 2)
This drug irreversibly inhibits the metabolism of dopamine by MAO-B (ONLY!! -> lower risk of HTN CRISIS) which results in increased dopamine levels in the brain
Selegiline
LAST DOSE SOULD BE EARLY AFTERNOON TO PREVENT INSOMNIA
(Lecture 2)
This MAOI has not yet had selectivity for MAO-B definitively established, but provides sx relief to PTs suffering from Parkinson’s and has possible neuroprotective effects
Rosagiline
- 5X MORE POTENT THAN SELEGILINE
- NOT METABOLIZED TO AMPHETAMINE
- HTN CRISIS POTENTIAL needs ADDITIONAL TESTING
- DO NOT take with TYRAMINE-containing foods
(Lecture 2) This class of drugs blocks the excitatory neurotransmitter ACTH to try and restore balance with dopamine
Anticholinergics
EX: Benzatropine; Trihexyphenidyl
