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Psych pharm > MOAs > Flashcards

MOAs Flashcards

1
Q

Ethanol

A

Increased: (GABA, 5-HT, beta-endorphin, CB1, DA), decreased NMDA

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2
Q

Disulfiram

A

Inhibits aldehyde dehydrogenase

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3
Q

Naltrexone

A

Mu opioid antagonist

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4
Q

Acamprosate

A

GABAa agonist / NMDA antagonist

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5
Q

Fomepizole

A

Inhibits alcohol dehydrogenase

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6
Q

Benzodiazepines

A

Allosteric agonist for GABA receptor

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7
Q

Buspirone

A

Something to do with serotonin

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8
Q

Propranolol

A

Beta blocker

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9
Q

TCAs

A

Decreased reuptake of NE and 5-HT

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10
Q

Amoxapine

A

NE > 5-HT > DA reuptake inhibitor

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11
Q

Maprotiline

A

Selective NE reuptake inhibitor

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12
Q

Trazodone

A

5-HT modulator (+ a little SSRI)

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13
Q

Nefazodone

A

5-HT modulator (+ a little SSRI)

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14
Q

Mirtazepine

A

alpha2 antagonist –> increases release of 5-HT and NE

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15
Q

Bupropion

A

Blocks reuptake of DA, 5-HT, and NE

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16
Q

Venlafaxine

A

SNRI (zero antihistamine, anti-Ach, anti-NE effects)

17
Q

Duloxetine

A

SNRI (venlafaxine X100 potency)

18
Q

Vortioxetine

A

5-HT modulator (lots of different things)

19
Q

Vilazodone

A

5-HT modulator (+ a little SSRI)

20
Q

SSRIs

A

Inhibit reuptake of serotonin only

21
Q

MAOIs

A

Inhibit monoamine oxidase (increases lifespan of NE, 5-HT, tyramine, and DA

22
Q

Lithium

A

??? Interferes with IP3 signalling, neurotransmitter-mediated adenylate cyclase activity

23
Q

Valproate

A

Inhibits voltage gated Na channels, T-type Ca channels, GABA degredation. Stimulates K+ conductance, GABA synthesis

24
Q

Carbamazepine

A

Inhibits voltage-gated sodium channels

25
Q

Typical antipsychotics

A

D2 blockers

26
Q

Atypical antipsychotics

A

D2 blockers and 5-HT blockers

27
Q

Physostigmine

A

Cholinesterase inhibitor

28
Q

Bromocriptine

A

DA agonist

29
Q

St. John’s Wort

A

Increased levels of DA and 5-HT in CNS

30
Q

Amphetamine

A

Increase release of NE and DA

31
Q

Atomoxitine

A

Blocks NE reuptake

32
Q

Dexmethylphenidate

A

DA and NE reuptake inhibitor

33
Q

Methylphenidate

A

DA and NE reuptake inhibitor

34
Q

Clonidine

A

alpha 2 agonist

35
Q

Gaunfacine

A

Post-synaptic alpha 2 agonist

Psych pharm (3 decks)

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