MOA of drugs in the RAAS

Question 1

beta blockers

Answer 1

block beta one receptors, decrease HR and decrease force of contraction, decrease velocity of conduction through AV node, reduce renin secretion

Question 2

direct renin inhibitors

Answer 2

binds to AT blocking renin thereby inhibiting the cleavage of AT into AT I

Question 3

ACE I

Answer 3

inhibits AT converting enzyme reducing AT II causes vasodilation reduces aldosterone

Question 4

ARBs

Answer 4

block access to AT II to receptor
reduce vasoconstriction
reduce aldosterone secretion

Question 5

MRC

Answer 5

aldosterone receptor blockers
block receptors for aldosterone promote renal excretion of sodium and water preventing pathologic effects of aldosterone on cardiovascular structure and function