Moa Of Antibiotics

Question 1

MOA of penicillins (ie. Amoxicillin, flucoxacillin, penicillin G)

Answer 1

Inhibit the biosynthesis of cell wall mucopeptide by binding to penicillin binding proteins. Disrupting cell wall synthesis and therefore cell lysis occurs

Question 2

MOA of cephalosporins (ie. Cefuroxime, cefreiaxone, cefazolin)

Answer 2

Inhibit the biosynthesis of cell wall mucopeptide by binding to penicillin binding proteins . Therefore inhibiting cell wall synthesis and thus, cell lysis occurs

Question 3

MOA of vancomycin

Answer 3

Binds to the d-ala d-ala terminal during cell wall synthesis which inhibits transpeptidase

Question 4

MOA of isonazids

Answer 4

Prodrug that is activated by Kat-G. To form INH-NAD. Once activated it impedes the synthesis of mycolic acids by inhibiting INHA

Question 5

MOA of Ethambutamol

Answer 5

Inhibits the formation of arabinosyltransferase preventing the formation of arabinogalactan and lipoarabinomannan

Question 6

MOA of macrolides
e.g azythromycin ,erythromycin

Answer 6

Binds to the 23s rRNA on the 50s subunit which impedes the formation of this subunit and inhibits the translocation step of protein synthesis

Question 7

moa of tetracylcines (doxycycline, tetracycline)

Answer 7

Binds to the 30s ribosomal subunit prevent tRNA from binding inhibiting protein synthesis

Question 8

MOA of aminoglycosides (gentamicin, streptomycin)

Answer 8

Bind to the 16s rRNA on the 30s ribosome. This results in codon error

Question 9

moa fluoroquinolones ciproflaxin, levofloxacin

Answer 9

Targets DNA gyrase and topoisomerase IV. This prevents supercoiling inhibiting DNA replication

Question 10

Nitromidazoles (metronidazole)

Answer 10

Binds DNA to electron transport proteins blocking nucleus acid synthesis

Question 11

MOA of nitrofuratoins

Answer 11

Reduces nitrofuratoin reductase to form unstable metabolites

Question 12

Moa of rifampacin

Answer 12

Binds to the B subunit of rna polymerase, inhibiting rna synthesis

Question 13

Moa of sulfonamides

Answer 13

Inhibit the incorporation of paba into folic acid preventing folic acid synthesis

Question 14

Moa of trimethoprin

Answer 14

Inhibits dihydrofolate reductase decreasing folic acid synthesis

Question 15

What is the moa of chloramphenicol

Answer 15

Inhibits protein synthesis by combining with the 50s subunit and blocking transpeptidase and translocation functions