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Antibiotics.526 Infectious Disease > MOA: Inhibitors Of Cell Wall Synthesis > Flashcards

MOA: Inhibitors Of Cell Wall Synthesis Flashcards

1
Q

What is the spectrum of activity for Natural Penicillins?

A

Gram Positive Cocci: Streptococcus

Spirochetes
Treponema pallidum

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2
Q

Route of administration for Penicillin VK?

A

PO

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3
Q

What is the route of administration for Benzathine Penicillin (Bicillin L-A)?

A

IM

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4
Q

What are adverse effects of (Class) Natural Penicillins (Drug) Penicillin VK?

A

Hypersensitivity
Diarrhea
Rash

Severe:
Seizures, nephrotoxicity, Stevens-Johnson,Toxic epidermal necrolysis

Hypersensitivity
- Immediate Type I
reactions are the most
serious (anaphylaxis) - Delayed Type IV
morbilliform rash is
not dangerous
- Risk of Delayed Type II
or III reactions: serum
sickness, hemolytic
anemia,
thrombocytopenia,
nephritis, hepatitis,
drug fever
- 1-10% risk of cross-
sensitivity with
cephalosporins
  • “Ampicillin rash”
    (increased risk in pts
    with EBV or CLL – not
    an allergy)
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5
Q

What are adverse effects of (Class) Natural Penicillins (Drug) Bemzathine Penicillin (Bicillin L-A)?

A

Hypersensitivity
Diarrhea
Rash

Severe:
Seizures, nephrotoxicity, Stevens-Johnson,Toxic epidermal necrolysis

Hypersensitivity
- Immediate Type I
reactions are the most
serious (anaphylaxis) - Delayed Type IV
morbilliform rash is
not dangerous
- Risk of Delayed Type II
or III reactions: serum
sickness, hemolytic
anemia,
thrombocytopenia,
nephritis, hepatitis,
drug fever
- 1-10% risk of cross-
sensitivity with
cephalosporins
  • “Ampicillin rash”
    (increased risk in pts
    with EBV or CLL – not
    an allergy)
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6
Q

What are safety considerations for Penicillin VK?

A

Hypersensitive

Susceptible to
inactivation by beta-
lacatamase
(penicillinase) unless
paired with a
penicillinase inhibitor
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7
Q

What are safety considerations for Benzathine Penicillin (Bicillin L-A)?

A

Hypersensitivity

Susceptible to
inactivation by beta-
lacatamase
(penicillinase) unless
paired with a
penicillinase inhibitor
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8
Q

What is the spectrum of activity for Penicillinase-Resistant Penicillin?

A

Gram positive Cocci

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9
Q

Dicloxacillin works on what organisms?

A

Gram positive cocci

Penicillinase resistant Penicillins

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10
Q

What are adverse effects of dicloxacillin?

A

Hypersensitivity
Diarrhea
Rash

Severe:
Seizures, nephrotoxicity, Stevens-Johnson,Toxic epidermal necrolysis

Hypersensitivity
- Immediate Type I
reactions are the most
serious (anaphylaxis) - Delayed Type IV
morbilliform rash is
not dangerous
- Risk of Delayed Type II
or III reactions: serum
sickness, hemolytic
anemia,
thrombocytopenia,
nephritis, hepatitis,
drug fever
- 1-10% risk of cross-
sensitivity with
cephalosporins
  • “Ampicillin rash”
    (increased risk in pts
    with EBV or CLL – not
    an allergy)
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11
Q

What are Adverse Effects of Methicillin?

A

Hypersensitivity
Diarrhea
Rash

Severe:
Seizures, nephrotoxicity, Stevens-Johnson,Toxic epidermal necrolysis

Hypersensitivity
- Immediate Type I
reactions are the most
serious (anaphylaxis) - Delayed Type IV
morbilliform rash is
not dangerous
- Risk of Delayed Type II
or III reactions: serum
sickness, hemolytic
anemia,
thrombocytopenia,
nephritis, hepatitis,
drug fever
- 1-10% risk of cross-
sensitivity with
cephalosporins
  • “Ampicillin rash”
    (increased risk in pts
    with EBV or CLL – not
    an allergy)
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12
Q

Is Methicillin only used in lab testing?

A

Yes

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13
Q

What are adverse effects of Methicillin?

A

Hypersensitivity
Diarrhea
Rash

Severe:
Seizures, nephrotoxicity, Stevens-Johnson,Toxic epidermal necrolysis

Hypersensitivity
- Immediate Type I
reactions are the most
serious (anaphylaxis) - Delayed Type IV
morbilliform rash is
not dangerous
- Risk of Delayed Type II
or III reactions: serum
sickness, hemolytic
anemia,
thrombocytopenia,
nephritis, hepatitis,
drug fever
- 1-10% risk of cross-
sensitivity with
cephalosporins
  • “Ampicillin rash”
    (increased risk in pts
    with EBV or CLL – not
    an allergy)
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14
Q

What is the Drug Class of Amoxicillin (Amoxil, Moxatag)?

A

Extended Spectrum Penicillin

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15
Q

What is the Drug Class of Ampicillin (Omipen)?

A

Extended Spectrum Penicillin

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16
Q

What is the spectrum of activity for Penicillin VK?

A

Gram Positive Cocci
-Streptococcus

Spirochetes
-Treponema Pallidum

17
Q

What is the spectrum of activity for Benzathine Penicillin (Bicillin L-A)?

A

Gram Positive Cocci
-Streptococcus

Spirochetes
-Treponema Pallidum

18
Q

What is the spectrum of activity for Dicloxacillin?

A

Gram positive Cocci

19
Q

What is the Spectrum of Activity for Amoxicillin (Amoxil, Moxatag)?

A

Gram positive Cocci and Listeria Monocytogenes

20
Q

What is the spectrum of activity for Ampicillin (Omnipen)?

A

Gram positive Cocci and Listeria Monocytogenes

21
Q

What is the route of administration for Amoxicillin?

22
Q

What is the route of administration for Ampicillin?

23
Q

What are adverse effects of Amoxicillin?

A

Hypersensitivity
Diarrhea
Rash

Severe:
Seizures, nephrotoxicity, Stevens-Johnson,Toxic epidermal necrolysis

Hypersensitivity
- Immediate Type I
reactions are the most
serious (anaphylaxis) - Delayed Type IV
morbilliform rash is
not dangerous
- Risk of Delayed Type II
or III reactions: serum
sickness, hemolytic
anemia,
thrombocytopenia,
nephritis, hepatitis,
drug fever
- 1-10% risk of cross-
sensitivity with
cephalosporins
  • “Ampicillin rash”
    (increased risk in pts
    with EBV or CLL – not
    an allergy)
24
Q

What are adverse effects of Ampicillin?

A

Hypersensitivity
Diarrhea
Rash

Severe:
Seizures, nephrotoxicity, Stevens-Johnson,Toxic epidermal necrolysis

Hypersensitivity
- Immediate Type I
reactions are the most
serious (anaphylaxis) - Delayed Type IV
morbilliform rash is
not dangerous
- Risk of Delayed Type II
or III reactions: serum
sickness, hemolytic
anemia,
thrombocytopenia,
nephritis, hepatitis,
drug fever
- 1-10% risk of cross-
sensitivity with
cephalosporins
  • “Ampicillin rash”
    (increased risk in pts
    with EBV or CLL – not
    an allergy)
25
Q

What are safety considerations for Amoxicillin?

A

Hypersensitive

Susceptible to
inactivation by beta-
lacatamase
(penicillinase) unless
paired with a
penicillinase inhibitor
26
Q

What are Safety Considerations for Ampicillin?

A

Hypersensitive

Susceptible to
inactivation by beta-
lacatamase
(penicillinase) unless
paired with a
penicillinase inhibitor

Antibiotics.526 Infectious Disease (1 decks)

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