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Pulmonology: Pharmacology > MOA & Indications > Flashcards

MOA & Indications Flashcards

1
Q

What is the mechanism of action for
Fluticasone
[Flovent]?

A

Fluticasone [Flovent] is an anti-inflammatory, immunosuppressive & anti-proliferative activity

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2
Q

What is the mechanism of action for

Prednisone Generic?

A

Prednisone Generic is an anti-inflammatory early after administration by decreasing migration of WBCs, reversal capillary permeability, immunosuppressant; later onset of inhibition of protein synthesis

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3
Q

What is the mechanism of action for
Cromolyn MDI
[Crolom] or
[Intal]?

A

Cromolyn MDI
[Crolom] or [Intal] stabilizes mast cell membrane to prevent degranulation and release of histamine, leukotrienes, slow-reacting substance of anaphylaxis

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4
Q

What is the mechanism of action for
Zafirlukast
[Accolate]?

A

Zafirlukast [Accolate] is a selective and competitive antagonist of leukotriene receptors D4 & E4, SRSA

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5
Q

What is the mechanism of action for
Salmeterol
[Serevent Diskus]?

A

Salmeterol [Serevent Diskus] is a selective, long-acting Beta2 adrenergic agonist

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6
Q

What is the mechanism of action for
Formoterol
[Foradil]?

A

Formoterol [Foradil] is a long acting Beta2 agonist

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7
Q

What is the mechanism of action for Albuterol

[Ventolin HFA]?

A

Albuterol [Ventolin HFA] is a bronchial smooth muscle Beta2 (sympathetic) receptor stimulation; racemic mixture w/ R isomer active & S isomer inactive (?side effects)

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8
Q

What is the mechanism of action for Theophyline

[Elixophyllin]?

A

Theophyline [Elixophyllin] is a PDE blockade that causes incr levels cAMP which produces bronchodilation, diuresis, CNS and cardiac stimulation, release of epinephrine

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9
Q

What is the mechanism of action for Levalbuterol

[Xopenex HFA]?

A

Levalbuterol [Xopenex HFA] is a rapid acting selective Beta2 receptor agonist which counteracts bronchospasm; pure R-isomer of drug

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10
Q

What is the mechanism of action for
Tiotropium
[Spiriva]?

A

Tiotropium [Spiriva] blocks acetylcholine at parasympathetic receptors in bronchial smooth muscle producing bronchodilatation

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11
Q

What is the mechanism of action for Ipratropium HFA

[Atrovent HFA]?

A

Ipratropium HFA [Atrovent HFA] blocks acetylcholine cholinergic receptors in bronchial smooth muscle to reduce bronchospasm

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12
Q

What is the mechanism of action for
Umeclidinium & Vilanterol
[Anoro Ellipta]?

A

Umeclidinium & Vilanterol
[Anoro Ellipta] are a combination of two agents with different bronchodilating action (anti-muscarinic and beta2 agonism)

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13
Q

What is the mechanism of action for
Fluticasone/Salmeterol HFA MDI
[Advair HFA]
[Advair Diskus]?

A

Fluticasone/Salmeterol HFA MDI
[Advair HFA] & [Advair Diskus] use anti-inflammatory action of steroid and bronchodilitation activity of Beta2 agonist

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14
Q

What is the mechanism of action for
Ipratropium/Albuterol
[Combivent]?

A

Ipratropium/Albuterol [Combivent] are anticholinergic and Beta2 agonist bronchodilators

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15
Q

What is the mechanism of action for
Budesonide/Formoterol
[Symbicort MDI]?

A

Budesonide/Formoterol [Symbicort MDI] is an anti-inflammatory action of steroid and bronchodilitation activity of Beta2 agonist

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16
Q

What is the mechanism of action for Roflumilast

[Daliresp]?

A

Roflumilast [Daliresp] is a drug and active metabolite inhibiting PDE4 increasing cAMP in inflammatory and structural cells; suppress cytokine release; inhibit lung infiltration by WBC’s; decreases pulmonary remodeling

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17
Q

What is the mechanism of action for Omalizumab

[Xolair]?

A

Omalizumab [Xolair] binds to IgE antibody receptors on mast cells, blocking attachment of IgE antibody and preventing degranulation release of histamines, leukotrienes

18
Q 
What is the mechanism of action for
[Nicoderm Patch]
[Nicorette Gum]
[Nicotrol Inhaler]
[Nicotrol Nasal Spray]?
A

[Nicoderm Patch]
[Nicorette Gum]
[Nicotrol Inhaler]
[Nicotrol Nasal Spray] are biphasic CNS & ANS nicotine receptor stimulant; low dose -> stimulation ANS ganglia; large dose -> stim followed by blockade of transmission

19
Q

What is the mechanism of action for
Varenicline
[Chantix]?

A

Varenicline [Chantix] prevents nicotine stimulation of the mesolimbic dopamine system

20
Q

What is the mechanism of action for
Bupropion
[Wellbrutin]
[Zyban]?

A

Bupropion [Wellbrutin] [Zyban] has an unknown MOA

21
Q

What are the indications for

Fluticasone [Flovent]?

A

Asthma, COPD

22
Q

What are the indications for

Prednisone Generic?

A

Adjunct therapy in exacerbation of bronchospasm; multiple others

23
Q

What are the indications for
Cromolyn MDI
[Crolom] or
[Intal]?

A

Childhood asthma

24
Q

What are the indications for
Zafirlukast
[Accolate]?

A

Asthma

25
Q

What are the indications for
Salmeterol
[Serevent Diskus]?

A

long term control of COPD, asthma control; EIB

26
Q

What are the indications for
Formoterol
[Foradil]?

A

long term control COPD, asthma with steroid MDI

27
Q

What are the indications for
Albuterol
[Ventolin HFA]?

A

Bronchospasm in asthma & COPD, EIB

28
Q

What are the indications for
Theophyline
[Elixophyllin]?

A

reversal of bronchospasm

29
Q

What are the indications for
Levalbuterol
[Xopenex HFA]?

A

treatment or prevention of bronchospasm in reversible airway disease (Asthma, EIB, COPD)

30
Q

What are the indications for
Tiotropium
[Spiriva]?

A

maintenance Tx bronchospasm in COPD, asthma

31
Q

What are the indications for
Ipratropium HFA
[Atrovent HFA]?

A

acute and maintenance Tx of bronchospasm in COPD, asthma

32
Q

What are the indications for
Umeclidinium & Vilanterol
[Anoro Ellipta]?

A

COPD

33
Q

What are the indications for Fluticasone/Salmeterol HFA MDI
[Advair HFA]
[Advair Diskus]?

A

Asthma (maintenance of bronchodilation), Asthma

34
Q

What are the indications for Ipratropium/Albuterol

[Combivent]?

A

COPD pts requiring two bronchodilators

35
Q

What are the indications for Budesonide/Formoterol

[Symbicort MDI]?

A

Asthma (maintenance of bronchodilation); COPD

36
Q

What are the indications for
Roflumilast
[Daliresp]?

A

Adjunct therapy in COPD (chronic bronchitis)

37
Q

What are the indications for
Omalizumab
[Xolair]?

A

maintenance Tx allergic asthma not controlled by inhaled steroids

38
Q 
What are the indications for
[Nicoderm Patch]
[Nicorette Gum]
[Nicotrol Inhaler]
[Nicotrol Nasal Spray]?
A

tobacco cessation aid

AKA STOP SMOKING!!

39
Q

What are the indications for
Varenicline
[Chantix]?

A

tobacco cessation aid

AKA STOP SMOKING!!

40
Q

What are the indications for
Bupropion
[Wellbrutin]
[Zyban]?

A

tobacco cessation [Zyban];

depression [Wellbutrin]

Pulmonology: Pharmacology (1 decks)

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