MOA & Indications Flashcards
What is the mechanism of action for
Fluticasone
[Flovent]?
Fluticasone [Flovent] is an anti-inflammatory, immunosuppressive & anti-proliferative activity
What is the mechanism of action for
Prednisone Generic?
Prednisone Generic is an anti-inflammatory early after administration by decreasing migration of WBCs, reversal capillary permeability, immunosuppressant; later onset of inhibition of protein synthesis
What is the mechanism of action for
Cromolyn MDI
[Crolom] or
[Intal]?
Cromolyn MDI
[Crolom] or [Intal] stabilizes mast cell membrane to prevent degranulation and release of histamine, leukotrienes, slow-reacting substance of anaphylaxis
What is the mechanism of action for
Zafirlukast
[Accolate]?
Zafirlukast [Accolate] is a selective and competitive antagonist of leukotriene receptors D4 & E4, SRSA
What is the mechanism of action for
Salmeterol
[Serevent Diskus]?
Salmeterol [Serevent Diskus] is a selective, long-acting Beta2 adrenergic agonist
What is the mechanism of action for
Formoterol
[Foradil]?
Formoterol [Foradil] is a long acting Beta2 agonist
What is the mechanism of action for Albuterol
[Ventolin HFA]?
Albuterol [Ventolin HFA] is a bronchial smooth muscle Beta2 (sympathetic) receptor stimulation; racemic mixture w/ R isomer active & S isomer inactive (?side effects)
What is the mechanism of action for Theophyline
[Elixophyllin]?
Theophyline [Elixophyllin] is a PDE blockade that causes incr levels cAMP which produces bronchodilation, diuresis, CNS and cardiac stimulation, release of epinephrine
What is the mechanism of action for Levalbuterol
[Xopenex HFA]?
Levalbuterol [Xopenex HFA] is a rapid acting selective Beta2 receptor agonist which counteracts bronchospasm; pure R-isomer of drug
What is the mechanism of action for
Tiotropium
[Spiriva]?
Tiotropium [Spiriva] blocks acetylcholine at parasympathetic receptors in bronchial smooth muscle producing bronchodilatation
What is the mechanism of action for Ipratropium HFA
[Atrovent HFA]?
Ipratropium HFA [Atrovent HFA] blocks acetylcholine cholinergic receptors in bronchial smooth muscle to reduce bronchospasm
What is the mechanism of action for
Umeclidinium & Vilanterol
[Anoro Ellipta]?
Umeclidinium & Vilanterol
[Anoro Ellipta] are a combination of two agents with different bronchodilating action (anti-muscarinic and beta2 agonism)
What is the mechanism of action for
Fluticasone/Salmeterol HFA MDI
[Advair HFA]
[Advair Diskus]?
Fluticasone/Salmeterol HFA MDI
[Advair HFA] & [Advair Diskus] use anti-inflammatory action of steroid and bronchodilitation activity of Beta2 agonist
What is the mechanism of action for
Ipratropium/Albuterol
[Combivent]?
Ipratropium/Albuterol [Combivent] are anticholinergic and Beta2 agonist bronchodilators
What is the mechanism of action for
Budesonide/Formoterol
[Symbicort MDI]?
Budesonide/Formoterol [Symbicort MDI] is an anti-inflammatory action of steroid and bronchodilitation activity of Beta2 agonist
What is the mechanism of action for Roflumilast
[Daliresp]?
Roflumilast [Daliresp] is a drug and active metabolite inhibiting PDE4 increasing cAMP in inflammatory and structural cells; suppress cytokine release; inhibit lung infiltration by WBC’s; decreases pulmonary remodeling
What is the mechanism of action for Omalizumab
[Xolair]?
Omalizumab [Xolair] binds to IgE antibody receptors on mast cells, blocking attachment of IgE antibody and preventing degranulation release of histamines, leukotrienes
What is the mechanism of action for [Nicoderm Patch] [Nicorette Gum] [Nicotrol Inhaler] [Nicotrol Nasal Spray]?
[Nicoderm Patch]
[Nicorette Gum]
[Nicotrol Inhaler]
[Nicotrol Nasal Spray] are biphasic CNS & ANS nicotine receptor stimulant; low dose -> stimulation ANS ganglia; large dose -> stim followed by blockade of transmission
What is the mechanism of action for
Varenicline
[Chantix]?
Varenicline [Chantix] prevents nicotine stimulation of the mesolimbic dopamine system
What is the mechanism of action for
Bupropion
[Wellbrutin]
[Zyban]?
Bupropion [Wellbrutin] [Zyban] has an unknown MOA
What are the indications for
Fluticasone [Flovent]?
Asthma, COPD
What are the indications for
Prednisone Generic?
Adjunct therapy in exacerbation of bronchospasm; multiple others
What are the indications for
Cromolyn MDI
[Crolom] or
[Intal]?
Childhood asthma
What are the indications for
Zafirlukast
[Accolate]?
Asthma
What are the indications for
Salmeterol
[Serevent Diskus]?
long term control of COPD, asthma control; EIB
What are the indications for
Formoterol
[Foradil]?
long term control COPD, asthma with steroid MDI
What are the indications for
Albuterol
[Ventolin HFA]?
Bronchospasm in asthma & COPD, EIB
What are the indications for
Theophyline
[Elixophyllin]?
reversal of bronchospasm
What are the indications for
Levalbuterol
[Xopenex HFA]?
treatment or prevention of bronchospasm in reversible airway disease (Asthma, EIB, COPD)
What are the indications for
Tiotropium
[Spiriva]?
maintenance Tx bronchospasm in COPD, asthma
What are the indications for
Ipratropium HFA
[Atrovent HFA]?
acute and maintenance Tx of bronchospasm in COPD, asthma
What are the indications for
Umeclidinium & Vilanterol
[Anoro Ellipta]?
COPD
What are the indications for Fluticasone/Salmeterol HFA MDI
[Advair HFA]
[Advair Diskus]?
Asthma (maintenance of bronchodilation), Asthma
What are the indications for Ipratropium/Albuterol
[Combivent]?
COPD pts requiring two bronchodilators
What are the indications for Budesonide/Formoterol
[Symbicort MDI]?
Asthma (maintenance of bronchodilation); COPD
What are the indications for
Roflumilast
[Daliresp]?
Adjunct therapy in COPD (chronic bronchitis)
What are the indications for
Omalizumab
[Xolair]?
maintenance Tx allergic asthma not controlled by inhaled steroids
What are the indications for [Nicoderm Patch] [Nicorette Gum] [Nicotrol Inhaler] [Nicotrol Nasal Spray]?
tobacco cessation aid
AKA STOP SMOKING!!
What are the indications for
Varenicline
[Chantix]?
tobacco cessation aid
AKA STOP SMOKING!!
What are the indications for
Bupropion
[Wellbrutin]
[Zyban]?
tobacco cessation [Zyban];
depression [Wellbutrin]
