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Pharm II > MOA Exam 1 > Flashcards

MOA Exam 1 Flashcards

1
Q

Topical Immunosuppressants (Tacrolimus & Pimecrolimus)

A

Bind & inhibit calcineurin; inhibits T-cell activation

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2
Q

Bacitracin

A

inhibits NAG & NAM transport across cell membrane

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3
Q

Polymyxin B

A

binds LPS; disrupting cell membrane

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4
Q

Mupirocin

A

inhibits iso-leucyl-tRNA synthetase; inhibiting protein synthesis

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5
Q

Retapamulin

A

binds 50S ribosomal subunit

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6
Q

Azole Antifungals

A

inhibits lanosterol-14a-demethylase

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7
Q

Allylamines & Tolnaftate

A

Inhibits squalene epoxidase

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8
Q

Griseofulvin

A

deposits into keratin; binds to fungal microtubules

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9
Q

Ciclopirox

A

(suspected) chelates iron; iron-dependent enzymes fail to function

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10
Q

Tavaborole

A

inhibits leucyl-tRNA synthetase

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11
Q

Acyclovir & Penciclovir

A

host converts to triphosphate form that inhibits viral DNA synthase

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12
Q

Docosanol (Abreva)

A

inhibits fusion of viral coat to cell membrane

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13
Q

Podophyllum & Podofilox

A

likely inhibition of Topoisomerase II

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14
Q

Benzoyl Peroxide

A

inhibits P. acnes

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15
Q

Dapsone

A

similar to sulfas

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16
Q

Retinoids

A

increases epidermal cell turnover; decreases sebum production

17
Q

Metronidazole

A

forms free radical (systemic admin); active against D. brevis (topically)

18
Q

Azelaic Acid

A

inhibits P. acnes; decreases DHT production in skin

19
Q

Salicylic Acid

A

denatures fibers holding neighboring keratinocytes together

20
Q

Coal Tar

A

intercalates w/ DNA, causing damage; produces free radicals

21
Q

Calcipotriene

A

alters gene expression; decreases epidermal cell division; decreases lymphocyte activation

22
Q

Apremilast

A

PDE4 inhibitor; decreases TNF-alpha production

23
Q

Cyclosporine A

A

same as topical immunosuppressants

24
Q

Methotrexate

A

DHFR inhibitor; decreases folate activation

25
Q

Etanercept, Infliximab, Adalimumab, Golimumab

A

TNF-inhibitors; decrease amount or activity of TNF-alpha

26
Q

Ustekinumab

A

antibody against IL 12 & 23

27
Q

Alefacept

A

decreases T-cell activation and CD2+ cell counts

28
Q

Efalizumab

A

decreases migration and activation of T-cells

29
Q

Secukinumab & Ixekizumab

A

antibodies against IL 17

30
Q

Permethrin

A

pyrethroid type insecticide; neuronal depolarization via VGNaCs

Pharm II (5 decks)

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