MOA Exam 1 Flashcards
Topical Immunosuppressants (Tacrolimus & Pimecrolimus)
Bind & inhibit calcineurin; inhibits T-cell activation
Bacitracin
inhibits NAG & NAM transport across cell membrane
Polymyxin B
binds LPS; disrupting cell membrane
Mupirocin
inhibits iso-leucyl-tRNA synthetase; inhibiting protein synthesis
Retapamulin
binds 50S ribosomal subunit
Azole Antifungals
inhibits lanosterol-14a-demethylase
Allylamines & Tolnaftate
Inhibits squalene epoxidase
Griseofulvin
deposits into keratin; binds to fungal microtubules
Ciclopirox
(suspected) chelates iron; iron-dependent enzymes fail to function
Tavaborole
inhibits leucyl-tRNA synthetase
Acyclovir & Penciclovir
host converts to triphosphate form that inhibits viral DNA synthase
Docosanol (Abreva)
inhibits fusion of viral coat to cell membrane
Podophyllum & Podofilox
likely inhibition of Topoisomerase II
Benzoyl Peroxide
inhibits P. acnes
Dapsone
similar to sulfas
Retinoids
increases epidermal cell turnover; decreases sebum production
Metronidazole
forms free radical (systemic admin); active against D. brevis (topically)
Azelaic Acid
inhibits P. acnes; decreases DHT production in skin
Salicylic Acid
denatures fibers holding neighboring keratinocytes together
Coal Tar
intercalates w/ DNA, causing damage; produces free radicals
Calcipotriene
alters gene expression; decreases epidermal cell division; decreases lymphocyte activation
Apremilast
PDE4 inhibitor; decreases TNF-alpha production
Cyclosporine A
same as topical immunosuppressants
Methotrexate
DHFR inhibitor; decreases folate activation
Etanercept, Infliximab, Adalimumab, Golimumab
TNF-inhibitors; decrease amount or activity of TNF-alpha
Ustekinumab
antibody against IL 12 & 23
Alefacept
decreases T-cell activation and CD2+ cell counts
Efalizumab
decreases migration and activation of T-cells
Secukinumab & Ixekizumab
antibodies against IL 17
Permethrin
pyrethroid type insecticide; neuronal depolarization via VGNaCs
