MOA

Question 1

HCTZ

Answer 1

Inc Na, Cl excretion by dec reabsorption

Question 2

spironolactone

Answer 2

Competitive aldosterone antagonist

Blocks Na/K exchange → mild/delayed diuresis

Inc Na, Cl excretion
Dec K, Mg excretion

Question 3

Triamterene-HCTZ

Answer 3

Potassium sparing

Acts of active Na exchange for K and H → prod mild diuresis

Thiazide inc Na, Cl excretion

Question 4

Chlorthalidone

Answer 4

Inc Na, Cl excretion by interfering w/ reabsorption

Question 5

Furosemide (Lasix)

Answer 5

inhibiting the luminal Na-K-Cl cotransporter by binding to the chloride transport channe

Na-K-Cl loss in urine

Question 6

statins

Answer 6

HMG-CoA reductase inhibitor

Question 7

Fenofibrate

Answer 7

Inc lipolysis and elimination of triglyceride rich particles

Question 8

Ezetimibe (Zetia)

Answer 8

Inhibits cholesterol absorption leading to a dec in delivery of cholesterol to the liver

Question 9

Gemfibrozil

Answer 9

Inc lipolysis and elimination of triglyceride rich particles

Question 10

Isosorbide mononitrate

Answer 10

NO activates guanylate cyclase → inc cGMP → dec intracellular Ca → direct relaxation of vascular smooth muscle

Question 11

Nitroglycerin

Answer 11

NO activates guanylate cyclase → inc cGMP → dec intracellular Ca → direct relaxation of vascular smooth muscle

Question 12

Digoxin

Answer 12

Improved Ca availability to myocardial contractile elements

Question 13

Amiodarone

Answer 13

prolongs effective refractory period of atrial & ventricular tissue by blocking potassium conductance.

Question 14

Warfarin

Answer 14

Prevents vit K conversion back to its active form

Impairs formation of clotting factors II, VII, IX, and X

Question 15

-xabans

Answer 15

Factor Xa inhibitor

Question 16

Clopidogrel

Answer 16

Direct inhibition of ADP binding to receptor sites

Inhibits gpIIb/IIIa complex