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ID Pharmacology > MOA > Flashcards

MOA Flashcards

1
Q

Inhibits viral DNA synthesis and viral replication

A

Acyclovir

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2
Q

Inhibits uncoating of influenza A virus preventing penetration of virus into host; dopamine agonist

A

Amantadine

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3
Q

Prodrug converted to active form and inhibits cleaving of virus from cellular envelope preventing release

A

Tamiflu

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4
Q

Inhibits cleaving of virus from cellular envelope preventing release

A

Relenza

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5
Q

Inhibits replication DNA, RNA viruses via inhibition of protein synthesis

A

Ribavirin

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6
Q

Inhibits viral RNA to DNA transcription

A

Epivir

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7
Q
  1. Binds to specific cell membrane receptors inhibiting viral penetration, translation, transcription, protein processing, maturation, and release; 2. increases phagocytic activity macrophages; 3. increases number and survival of cytotoxic T cells
A

Peg Interferon Alfa2a (Pegasys)

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8
Q

Direct acting antiviral against Hep C virus; prodrug that is converted to active form intracellularly and inhibits HCV NS5B RNA-dependent polymerase needed for viral replication and acts as a chain terminator.

A

Sovaldi

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9
Q

Ledipasvir inhibits HCV NS5A protein needed for viral replication; Sofosbuvir inhibits NS5B RNA-dependent RNA polymerase needed for viral replication and acts as a chain terminator

A

Harvoni

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10
Q

Inhibits bacterial RNA synthesis by blocking RNA transcription

A

Rifampin

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11
Q

Possibly interruption of mycolic acid synthesis resulting in disruption of bacterial cell wall

A

Isoniazid

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12
Q

Increases accumulation of toxic free heme in parasite

A

Chloroqine Sulfate

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13
Q

Disrupts helical DNA structure and causes DNA strand breakage

A

Metronidazole

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14
Q

Tx acute and chronic intestinal amebiasis

A

Yodoxin

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15
Q

Tx infection hookworm, pinworm, ascariasis and trichuriasis

A

Vermox

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16
Q

Causes spastic paralysis and tegumental damage in helminths

A

Bitricide

17
Q

Delays sodium ion influx through nerve and cell membrane producing paralysis and death

A

Permethrin

18
Q

Inhibits several bacterial enzyme systems (including acetyl CoA) interfering with metabolism and possibly cell wall synthesis

A

Macrobid

ID Pharmacology (3 decks)

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