MOA?

Question 1

Metformin

Answer 1

Decreases gluconeogenesis
Decreases GI absorption of glucose
Increases peripheral glucose uptake

Question 2

Sulfonylureas (glipizide, glyburide, glimepiride)

Answer 2

Binds sulfonylurea receptor –> increased insulin synthesis and secretion

Question 3

Meglitinide (repaglinide, nateglinide)

Answer 3

Binds meglitinide receptor –> increased insulin synthesis and secretion

Question 4

Thiazolidinediones (pioglitazone, rosiglitazone)

Answer 4

Agonizes PPAR-gamma receptor –> increased peripheral insulin sensitivity

Question 5

GLP-1 Agonists (exenatide, liraglutide, albiglutide)

Answer 5

Agonizes GLP-1 receptors –> increased insulin synthesis and secretion
Slows gastric emptying

Question 6

Alpha-glucosidase Inhibitors (acarbose, miglitol)

Answer 6

Inhibits GI enzyme (alpha glucosidase) that converts complex to simple sugars –> decreased glucose absorption

Question 7

DPP-4 Inhibitors (sitagliptin, linagliptin)

Answer 7

Inhibits somatic enzyme (DDP-4) that metabolizes GLP-1 and GIP –> increased insulin synthesis and secretion

Question 8

SGLT-2 Inhibitors

Answer 8

Inhibits proximal renal tubule enzyme (SGLT-2) that reabsorbs 90% of glucose –> glucosuria